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Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers

2015-07-21 12:23:23 | BioPortfolio

Summary

The purpose of this study is to compare the diagnostic validity (sensitivity and specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial provocation tests with the Wright and Devilbiss646 nebulizers in asthmatic in Guangzhou.

Description

After screening,each asthmatic patient will visit the investigators' center 4 times.

During the first week, the patient will be randomised to undergo methacholine bronchial challenge with Wright or Devilbiss 646 nebulizer on two separate days, which are at least 24 hours but not more than 7 days apart.The above procedure will be repeated for each patient in one month. But the nebulizer will be selected in a reverse order.Provocative concentration induced a 20% decrease in forced expiratory volume in one second (PC20) will be calculated for each test. Record all the adverse events during the tests.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Asthma

Intervention

methacholine, Wright Nebulizer, Devilbiss646 Nebulizer

Location

Guangzhou institute of respiratory disease
Guangzhou
Guangdong
China
510120

Status

Recruiting

Source

Guangzhou Institute of Respiratory Disease

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-07-21T12:23:23-0400

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