Stopping Cavities Study: Diamine Silver Fluoride

2015-08-31 23:23:23 | BioPortfolio


This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.


Phase III RCT with two arms: (1) 38% diammine silver fluoride; (2) distilled fluoride free water. Subjects are 200 preschool children in good general health with untreated tooth decay. Intervention is topical application of the study drug to the open cavity. Primary outcome is caries activity at 14-21 days.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Dental Caries


38% diammine silver fluoride


Advantage Dental Plans
United States


Not yet recruiting


Advantage Dental Services, LLC

Results (where available)

View Results


Published on BioPortfolio: 2015-08-31T23:23:23-0400

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PubMed Articles [2368 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A source of inorganic fluoride which is used topically to prevent dental caries.

Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.

A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.

The predisposition to tooth decay (DENTAL CARIES).

Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.

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