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The gambling problem is characterized by a loss of control and an excessive focus on the gaming practice. Currently, the treatment of pathological gamblers is often complex and multidimensional, it notably includes psychological techniques including cognitive behavioral therapy and the use of psychotropic drugs.
In pathological gambling and addictions, craving (or urge to play) and loss of control are two essential clinical elements. The neurobiological level, they are associated with a dysfunction of dorsolateral prefrontal cortex (DLPFC) (Goldstein et al, 2001, Volkow and Goldstein, 2002).
One therapeutic avenues explored in addictions is repeated transcranial magnetic stimulation (rTMS).
Patients included in this study will have:
- An anatomical brain MRI (30 minutes).
- Two 20 minute sessions of rTMS (placebo and active), at the frequency of 10 Hz.
- Ladders and tests measuring their desire to play and their gaming behavior.
- Cognitive tests, to be carried out on a computer before and immediately after rTMS sessions.
- Recording heart rate to measure the autonomic nervous system activity
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
rTMS active then rTMS placebo, rTMS placebo then rTMS active
CHU de SAINT-ETIENNE
Centre Hospitalier Universitaire de Saint Etienne
Published on BioPortfolio: 2015-09-18T04:08:25-0400
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