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This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill patients will be randomized to intermittent infusion or continuous infusion of cefotaxime.
Critically ill patients have other pharmacokinetic/pharmacodynamic profiles than healthy volunteers. Suboptimal, both under- and overdosing of antibiotics is an important threat in this patient category. Given the time-dependent character of beta-lactam antibiotics continuous dosing as opposed to traditional intermittent dosing is likely to render better target attainment and maintenance and might improve clinical outcome.
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
University Medical Center Groningen
Not yet recruiting
University Medical Center Groningen
Published on BioPortfolio: 2015-09-28T07:43:41-0400
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Semisynthetic broad-spectrum cephalosporin.
Health care provided to a critically ill patient during a medical emergency or crisis.
Registered nurses with graduate degrees in nursing who provide care to pediatric patients who are acutely or critically ill.
A nursing specialty that deals specifically with the care of patients who are critically ill.
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.