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Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.

2015-09-28 07:43:41 | BioPortfolio

Summary

This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill patients will be randomized to intermittent infusion or continuous infusion of cefotaxime.

Description

Critically ill patients have other pharmacokinetic/pharmacodynamic profiles than healthy volunteers. Suboptimal, both under- and overdosing of antibiotics is an important threat in this patient category. Given the time-dependent character of beta-lactam antibiotics continuous dosing as opposed to traditional intermittent dosing is likely to render better target attainment and maintenance and might improve clinical outcome.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Critically Ill

Intervention

Cefotaxime

Location

University Medical Center Groningen
Groningen
Netherlands
9700 RB

Status

Not yet recruiting

Source

University Medical Center Groningen

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-09-28T07:43:41-0400

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