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Mannitol Versus Supportive Care in Ciguatera Fish Poisoning

2015-10-08 09:53:21 | BioPortfolio

Summary

Ciguatera poisoning, caused by the ingestion of ciguatoxin-containing fish, is a global public health concern. In the US, the vast majority of ciguatera poisonings occur in Florida, followed by Hawaii and California. Equipoise exists in the medical literature regarding the effectiveness of mannitol therapy in treatment of ciguatera poisoning. While there are many case reports attesting to its utility, the only randomized control trial (RCT) comparing mannitol therapy with supportive care failed to show any significant benefit from mannitol treatment for a variety of clinical outcomes. Investigators therefore propose a second, larger RCT to test this question.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Ciguatoxin

Intervention

Mannitol

Status

Not yet recruiting

Source

University of South Florida

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-10-08T09:53:21-0400

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PubMed Articles [76 Associated PubMed Articles listed on BioPortfolio]

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Mannitol, an osmotic diuretic, has been used to prevent acute kidney injury (AKI). However, studies have found divergent effects of intraoperative mannitol administration on postoperative AKI. We ther...

Medical and Biotech [MESH] Definitions

Phosphoric acid esters of mannitol.

Sugar alcohol dehydrogenases that have specificity for MANNITOL. Enzymes in this category are generally classified according to their preference for a specific reducing cofactor.

A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent.

A mushroom, Ganoderma lucidum, of the POLYPORALES order of basidiomycetous fungi. It has long been used in traditional Chinese medicine in various forms. Contains STEROLS; COUMARINS; MANNITOL; POLYSACCHARIDES; and triterpenoids.

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