Advertisement

Topics

Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia

2015-10-22 13:53:24 | BioPortfolio

Summary

This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.

Description

PRIMARY OBJECTIVES:

I. To determine the metabolic adaptations that occur following exposure to standard chemotherapeutic agents using peripheral blood mononuclear cells from acute myeloid leukemia (AML) patients.

OUTLINE:

Patients undergo collection of peripheral blood mononuclear cell (PBMC) samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, and western blot at baseline, 24, 48, and 72 hours after starting chemotherapy.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Recurrent Adult Acute Myeloid Leukemia

Intervention

Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis

Location

Comprehensive Cancer Center of Wake Forest University
Winston-Salem
North Carolina
United States
27157

Status

Not yet recruiting

Source

Comprehensive Cancer Center of Wake Forest University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-10-22T13:53:24-0400

Clinical Trials [3584 Associated Clinical Trials listed on BioPortfolio]

Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer

This research trial studies the use of targeted genomic analysis of blood and tissue samples from patients with cancer. Genomic sequencing is a laboratory method that is used to determine ...

Esophageal Cytology With FISH in Detecting Esophageal Cancer in in Participants Undergoing Esophago Gastro-Duodenoscopy or Upper Endoscopy.

This clinical trial studies whether esophageal cytology plus fluorescence in situ hybridization (FISH) is equal to or better than esophago-gastro-duodenoscopy (EGD) or upper endoscopy for ...

Different Factors Affecting Patients With Newly Diagnosed Bladder Cancer

RATIONALE: Studying different factors that effect patients with newly diagnosed bladder cancer may help doctors learn more about the disease, improve the ability to plan cancer treatment, ...

High Definition Single Cell Analysis in Colorectal Cancer

This research clinical trial studies high definition single cell analysis in blood and tissue samples from patients with colorectal cancer which has spread to the liver. High definition si...

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treat...

PubMed Articles [22283 Associated PubMed Articles listed on BioPortfolio]

Specimen Collection, Processing, Culture, and Biochemical Identification of Acinetobacter spp.

Specimen collection and processing is an important aspect of clinical microbiology laboratory. The reports are dependent on the quality of the specimen and the time between the collection and processi...

An Improved Specimen Handling Procedure for Pathogen Detection of the Cerebrospinal Fluid by Microscope.

In order to increase the detection rate of pathogenic microorganisms in CSF, an improved specimen handling procedure (ISHP) was created.

Evaluation of Specimen Types for Pima CD4 Point-of-Care Testing: Advantages of Fingerstick Blood Collection into an EDTA Microtube.

Effective point-of-care testing (POCT) is reliant on optimal specimen collection, quality assured testing, and expedited return of results. Many of the POCT are designed to be used with fingerstick ca...

Adequacy criteria for voided urine cytology using cytospin preparations.

Previous studies have suggested that urine cytology adequacy may be related to both specimen volume and cellularity.

Ionized magnesium and calcium concentration and their ratio in equine plasma samples as determined by a regulatory laboratory compared to a clinical reference laboratory.

Magnesium sulfate (MgSO ) is administered to calm competition horses. We evaluated the impact of regulatory requirements for the handling of blood samples on plasma ionized magnesium (iMg), ionized ca...

Medical and Biotech [MESH] Definitions

Laboratory processes prior to specimen analysis. These processes include study design, compliance of the subjects investigated, compliance in adherence to protocols, choice of specimens utilized and sample collection.

A technique for analysis of the chemical composition of molecules. A substance is bombarded with monochromatic ELECTRONS. Some of the electrons passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The energy loss is element dependent. Analysis of the energy loss spectrum reveals the elemental composition of a specimen. ENERGY-FILTERED TRANSMISSION ELECTRON MICROSCOPY is a type of electron energy loss spectroscopy carried out in electron microscopes specially outfitted to analyze the spectrum of electron energy loss.

Activation analysis in which the specimen is bombarded with neutrons. Identification is made by measuring the resulting radioisotopes. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.

Methods or procedures used to obtain samples of URINE.

More From BioPortfolio on "Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Leukemia
Leukemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader grou...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...


Searches Linking to this Trial