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A Study on the Mechanism of Cough Hypersensitivity

2015-10-29 14:53:21 | BioPortfolio

Summary

The aim of this study is described as follows,

1. To establish a validated method to test cough reflex sensitivity conducted by transient receptor potential vanilloid 1(TRPV1).

2. To observe the variance of cough reflex sensitivity conducted by transient receptor potential ankyrin 1(TRPA1) of chronic patients and the relationship between cough reflex sensitivity conducted by TRPA1 and conducted by TRPV1.

3. To study the distribution of TRPA1 and TRPV1 channels and their relationship to cough reflex sensitivity.

Description

This study is divided into two major part, Firstly,to observe the variance of cough reflex sensitivity of chronic cough patients and the relationship between it and airway inflammation.

1. Recruit chronic cough patients and healthy volunteers as subjects.

2. Help subjects to complete detailed history,physical examination,Hull airway reflux questionnaire,chest x-rays,induced sputum,blood routine test,pulmonary ventilation function test and histamine provocation test before they enter this study.

3. Complete allyl isothiocynate(AITC) cough provocation test the day subjects enter the study,then complete capsaicin(CAP)cough provocation test after 3 days.

4. To detect the substance P(SP),calcitonin gene-related peptide(CGRP),prostaglandin E2(PGE2),et al level in sputum supernatants.

Secondly,to observe the distribution of TRPA1,TRPV1 channels and the relationship between it and cough reflex sensitivity.

1)Recruit chronic cough patients and healthy volunteers and complete related examinations as mentioned before.

2)Collect mucosa specimens from upper trachea via endobronchial biopsy,and airway epithelial cells from 2nd or 3rd order bronchi via brushing.

3)Evaluate the expression level of TRPA1,TRPV1 of mucosa specimens of subjects by immunofluorescent assay and Image analysis software.

4)Cultivate airway epithelial cells from subjects and evaluate the expression of TRPV1,TRPA1 and functional changes of it.

Study Design

Observational Model: Case Control

Conditions

Cough

Location

Guangzhou Institute of Respiratory Disease
Guangzhou
Guangdong
China
520120

Status

Recruiting

Source

The First Affiliated Hospital of Guangzhou Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-10-29T14:53:21-0400

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