Study of Covalently Closed Circular DNA (cccDNA) in Liver Transplant Patients With B Virus Markers

2015-11-12 19:08:23 | BioPortfolio


The aim of this study is to validate in the context of liver transplantation, the interest of the cccDNA assay technique developed by the team of Professor Zoulim (INSERM U1052) on liver biopsy and correlate this assay cccDNA in hepatitis B virus (HBV) viral load and serum liver through several groups of patients at transplantation (on graft and native liver explant) and after transplantation.

Study Design

Time Perspective: Prospective


Liver Transplantation


cccDNA assay on liver biopsy


Service d'Hépatologie, Hôpital de la Croix-Rousse




Hospices Civils de Lyon

Results (where available)

View Results


Published on BioPortfolio: 2015-11-12T19:08:23-0500

Clinical Trials [5224 Associated Clinical Trials listed on BioPortfolio]

Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a

Serum HBV DNA is a referent but insufficient marker of therapeutic follow-up in chronic hepatitis B treatment. Intra hepatic cccDNA disappearance reflects HBV eradication in the liver. ...

Collection of Liver Tissue for Virologic Studies

This study will examine liver tissue to investigate the role of viral infections in fulminant hepatitis, liver failure, and profound bone marrow failure. All patients who are undergoing l...

The TOGETHER Project - Liver

To validate the use of a RNAseq-based peripheral blood assay in liver transplant recipients when correlated to liver biopsy results.

Liver Transplantation: Skeletal Effects

Fifty patients awaiting liver transplantation and 50 age and gender matched control subjects with normal liver function will be included in the study. The aim of this project is to compare...

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and ou...

PubMed Articles [11038 Associated PubMed Articles listed on BioPortfolio]

Two-stage recipient hepatectomy and left-liver transplantation to minimize risks in adult-to-adult living donor liver transplantation: new concepts.

The combination of two-stage total hepatectomy and partial liver transplantation (LT) for secondary unresectable liver-only malignancies is producing a great quantity of literature. In the first stage...

Liver transplantation in children with propionic acidaemia - medium term outcomes.

Liver transplantation (LT) for patients with propionic acidaemia (PA) is an emerging therapeutic option.

Trans-gastric Endoscopic Lumen-apposing Metal Stents for Intra-abdominal Fluid Collections after Living Donor Liver Transplantation.

Living donor liver transplantation (LDLT) is becoming an established procedure for treating patients with end-stage liver disease; however, small-for-size graft syndrome has been a major obstacle to t...

Extensive Thrombectomy as a Legitimate Strategy in Living Donor Liver Transplantation with Advanced Portal Vein Thrombosis.

We read with great interest the article recently published in Liver Transplantation by Ikegami and colleagues (1). This study compared the clinical results of patients with and without portal vein thr...

Arterial blood pressure at liver transplant evaluation predicts renal histology in candidates with renal dysfunction.

Renal dysfunction is common in liver transplant (LT) candidates but differentiating between reversible and irreversible renal injury can be difficult. Kidney biopsy might be helpful in differentiating...

Medical and Biotech [MESH] Definitions

Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.

Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.

The transference of a part of or an entire liver from one human or animal to another.

Single or multiple areas of PUS due to bacterial infection within the hepatic parenchyma. It can be caused by a variety of BACTERIA, local or disseminated from infections elsewhere such as in APPENDICITIS; CHOLECYSTITIS; PERITONITIS; and after LIVER TRANSPLANTATION.

Sudden liver failure in the presence of underlying compensated chronic LIVER DISEASE (e.g., LIVER CIRRHOSIS; HEPATITIS; and liver injury and failure) due to a precipitating acute hepatic insult.

More From BioPortfolio on "Study of Covalently Closed Circular DNA (cccDNA) in Liver Transplant Patients With B Virus Markers"

Quick Search

Relevant Topics

An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...

Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

Searches Linking to this Trial