Regulation of Intestinal and Hepatic Lipoprotein Particle Production by Blood Glucose in Humans

2015-11-19 20:43:32 | BioPortfolio


The purpose of study is to examine whether raised blood glucose enhances lipid particle production independent of effects on gastric emptying and pancreatic/ gastrointestinal hormone production.


This study will be performed on healthy, lean, non-diabetic males and females who will participate two studies each in random order, 4 to 6 weeks apart. Study A: lipoprotein turnover with intravenous infusion of normal saline. Study B: lipoprotein turnover i.v infusion of glucose. In both studies, subjects will drink a liquid formula every hour to remain in a constant fed state and will be under conditions of pancreatic clamp (with the infusion of hormones somatostatin, insulin, glucagon, growth hormone). Subjects will be blinded with regard to the treatments.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science




glucose or normal saline


Tornto General Hospital, UHN
M5G 1L7




University Health Network, Toronto

Results (where available)

View Results


Published on BioPortfolio: 2015-11-19T20:43:32-0500

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