Rate-limiting Amino Acids in Endurance-trained Athlete

2015-12-14 04:17:38 | BioPortfolio


Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

The biological value of protein depends on the amino acid composition. As liebig's law of the minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid. In this case, the first rate limiting amino acid determines protein intakes to maximize the protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the biological value of its protein diet.

The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. however, the IAAO method has never been utilized for determining the first rate limiting amino acid.

Therefore, the purpose of this study is to address of IAAO method to be applied for determining the rate-limiting amino acid in endurance athlete.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science


Increased Metabolic Requirement


Base protein intake, Sufficient protein intake, Base + BCAAs, Base + EAA, Base + NEAA


Active, not recruiting


University of Toronto

Results (where available)

View Results


Published on BioPortfolio: 2015-12-14T04:17:38-0500

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