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Dendritic Cell-precision T Cell for Neo-antigen in the Treatment of Advanced Biliary Tract Malignant Tumor

2015-12-17 04:38:22 | BioPortfolio

Summary

Objectives:

The purpose of this study is to evaluate the safety and prognosis of dendritic cell-precision T cell for neo-antigen in the treatment of advanced biliary tract malignant tumor.

Methods:

This study designs a novel therapy using dendritic cell-precision multiple antigen T cells. 40 patients will be enrolled. They are randomly divided into gemcitabine group and dendritic cell-precision T cell for neo-antigen combined with gemcitabine group. Gemcitabine treatments will be performed once a week with a total of six times. Dendritic cell-precision T cell for neo-antigen combined with gemcitabine treatment: Gemcitabine: once a week with a total of six times before 60 days prior to the start of drawing blood. Dendritic cell-precision T cell for neo-antigen: once per 3 weeks with a total of three periods. The mail clinical indicators are Progression-Free-Survival and Overall Survival.

Description

A total of 40 patients may be enrolled over a period of 1-2 years.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Biliary Tract Malignant Tumor

Intervention

Gemcitabine, Dendritic cell-precision T cell for neo-antigen combined with gemcitabine treatment

Location

Eastern Hepatobiliary Surgery Hospital
Shanghai
China
200438

Status

Recruiting

Source

Second Military Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-12-17T04:38:22-0500

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