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This research study is evaluating the use of Cardiac Magnetic Resonance Imaging (CMR) as a method of detecting early signs of damage to the heart that can be associated with adjuvant therapy of anthracycline (doxorubicin)-based combination chemotherapy followed by treatment with herceptin (trastuzumab for the treatment of (HER+) breast cancer.
HER 2 breast cancer that has been shown to respond well to adjuvant therapy of doxorubicin followed by trastuzumab. One of the side effects observed in women receiving this treatment is heart complications in which the heart muscle is weakened and no longer able to pump sufficient amounts of blood throughout the body. This complication can lead to the following symptoms: shortness of breath on exertion, swollen ankles and feet, lack of energy and a reduced capacity to carry out day-to-day activities.
This research study is focused on identifying the early signs of such heart complications using CMR, which may allow preventative treatment options to be made available in future.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
HER-2 Positive Breast Cancer
Cardiac Magnetic Resonance Imaging (CMR), Echocardiogram (ECHO)
Beth Israel Deaconess Medical Center
Not yet recruiting
Dana-Farber Cancer Institute
Published on BioPortfolio: 2016-01-28T16:53:24-0500
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Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.
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Cardiovascular disease (CVD)
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