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Air Pollution Study: The Effect of Ozone on the Lung

2016-02-04 18:08:24 | BioPortfolio

Summary

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Description

Subjects will be asked to come to the Rutgers EOHSI clinical center (Piscataway, NJ) for 5 study visits. A physical exam to determine eligibility will be done at the first study visit. If the subject is healthy and able to produce a sputum sample, he/she will then be scheduled for 2 3-hour exposure visits. One exposure will be to clean air and the other exposure will be to 0.2 ppm ozone. During the exposures, subjects will be requested to ride an exercise bicycle intermittently (approximately every 15 minutes). A follow-up visit for sputum collection will be scheduled either 24, 48, or 72 hours after each exposure visit. Blood, urine, and exhaled breath samples will also be collected at each visit.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Conditions

Air Pollution

Intervention

Clean Air, Ozone

Location

Environmental and Occupational Health Sciences Institute
Piscataway
New Jersey
United States
08854

Status

Recruiting

Source

Rutgers, The State University of New Jersey

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-02-04T18:08:24-0500

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