Assessment of Rheological Parameters of Human Sputum.

2016-02-16 21:38:24 | BioPortfolio


This is a proof of concept study. The aim of this study is to assess a device measuring rheological properties of human sputum of four populations :

- 10 patients with Broncho Chronic Obstructive Pulmonary Disease (COPD)

- 10 patients with asthma

- 10 patients with cystic fibrosis

- 10 healthy volunteers.


This study includes two visits to 48 hours apart.

During the first visit :

- Patients with COPD or cystic fibrosis will have a spontaneous expectoration

- Then all study participants will have an induced expectoration with hypertonic salin solution (4.5%).

During the second visit :

- Patients with COPD or cystic fibrosis will have a spontaneous expectoration

- Then, patients with COPD, asthma and healthy volunteers will have an induced expectoration with hypertonic salin solution (4.5%). Patients with cystic fibrosis will have a spontaneous expectoration 1 hour after an RhDNAse nebulization.

A control spirometry will be perform before each expectoration and during induced expectoration if necessary.

All sputum sample collected will be homogenized and then divided into two equal volumes in order to perform two separate rheological measurements of 15 minutes.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label




Expectoration and measurement of sputum rheological properties


Centre d'Investigation Clinique - INSERM 1406


Not yet recruiting


University Hospital, Grenoble

Results (where available)

View Results


Published on BioPortfolio: 2016-02-16T21:38:24-0500

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