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Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications

2016-03-07 02:59:31 | BioPortfolio

Summary

There are no reports involved the intestinal microbiota from Chinese infants with short bowel syndrome (SBS) under different clinical status. Alterations in the microbiota are closely correlated with the bile acids and short chain fatty acids metabolism as well as the intestinal immunity. A relatively comprehensive profile composed of microbial structure, microbial metabolism products and immune biomarkers in SBS infants may facilitate a better therapy strategy to complications occurred in SBS children.

Description

The investigators totally collected 26 fecal samples from 18 infants diagnosed with SBS during parenteral nutrition administration, and these samples were divided into three groups according to complications of enrolled patients at sampling time: asymptomatic group, central catheter-related blood stream infections group and liver injury group. 7 healthy infants with supplementary food were enrolled as control. Fecal microbiota, sIgA and calprotectin, bile acids and short chain fatty acids were also detected by 16S ribosomal ribonucleic acid (rRNA) gene sequencing, enzyme-linked immunosorbent assay and liquid/gas chromatography.

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Conditions

Short Bowel Syndrome

Intervention

Complications

Location

Ethics Committee of Xinhua Hospital
Shanghai
Shanghai
China
200092

Status

Completed

Source

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-03-07T02:59:31-0500

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