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Immune Response of Caudally Administrated Ketamine or Tramadol In Pediatric Lower Abdominal Surgery

2016-03-10 03:23:23 | BioPortfolio

Summary

Management of acute pain is one of the most important tasks of perioperative pediatric anesthesia. The alleviation of pain has been defined by the Society of Pediatric Anesthesia, on its 15th annual meeting as a basic human right, irrespective of age, treatment primary service responsible for the patient care. Pro-inflammatory cytokines increased by surgical trauma indirectly modulate pain through the release of substances like nitric oxide, oxygen free radicals, prostaglandins, and excitatory amino acids, inducing peripheral and central sensitivity and hyperalgesia. There has been growing interest in determining the possible immune consequences of analgesic administration for the management of postoperative pain

Description

90 children aged 3-10 years undergoing lower abdominal surgery will be randomized into 3 groups (30 patients in each group) to receive caudal block with bupivacaine (0.25%) 1mg/kg (group I) plus either ketamine 0.5 mg/kg (group II), or tramadol 1mg/kg (group ІIІ) just after the induction of general anesthesia without premedication. All children will be assessed for the post operative immune response by measuring interleukin 6 and 10 (IL-6 and IL-10) and Tumour Necrosing Factor-α (TNF-α) using enzyme-linked immunosorbent assay (ELISA) technique one hour preoperatively and three hours after incision.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Acute Pain

Intervention

Bupivacaine group, Ketamine, Tramadol

Location

Faculty of Medicine
Assiut
Egypt

Status

Recruiting

Source

Assiut University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-03-10T03:23:23-0500

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