Presence of Nanoparticles in the Amniotic Fluid

2016-03-29 10:08:22 | BioPortfolio


The nanoparticles (NP) are defined as particles whose size is no greater than 100 nanometers. However, their impact on health remains little evaluated.

Placental transfer of NP has been proven in many studies in vitro and in vivo in animals, and toxicity in the fetus has been studied in many animals. The investigators seem interesting at first to establish the mineralogical load in the amniotic fluid in humans.

The first objective of this study is to determine the mineralogical NP load, quantity and composition, in the amniotic fluid in pregnant women.


The analysis will be done on 100 amniotic fluid samples and 100 blood samples. Particle size analysis will be performed by a technique of dynamic light scattering, which permits the distribution by volume or by number of NP according to their size. Parallel to the different chemical species present in the sample must be measured by atomic emission spectrometry with inductively coupled plasma.

The results of this study will be useful for further studies on the fetal toxicity of NP in humans.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Intrauterine Disorder


Nanoparticles load


Chu Saint-Etienne
St Etienne


Not yet recruiting


Centre Hospitalier Universitaire de Saint Etienne

Results (where available)

View Results


Published on BioPortfolio: 2016-03-29T10:08:22-0400

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