ARV Concentrations in Hair

2016-05-12 00:38:21 | BioPortfolio


Hair samples from subjects on antiretroviral therapy, both HIV- and HIV+ patients with HIV RNA <50copies/mL for >6 months will be analyzed to investigate the influence of race, hair color and hair treatment on ARV response.


A small thatch of hair (approximately 20 strands) will be collected from 85 participants who are currently taking antiretrovirals (ARVs). Hair collection will be evenly distributed into color cohorts: Black, Brown, Blonde and Grey. Participants will need to be >80% adherent to their medication and have had an undetectable HIV RNA VL within the previous 6 months. In the lab, samples will be used to develop IR-MALDESI MSI hair protocols for high sensitivity and accuracy to quantify ARVs in 5 therapeutic drug classes (Integrase Inhibitors, Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, Entry Inhibitors, Protease Inhibitors).

Study Design

Observational Model: Cohort, Time Perspective: Prospective




Hair analysis


University of North Carolina at Chapel Hill
Chapel Hill
North Carolina
United States




University of North Carolina, Chapel Hill

Results (where available)

View Results


Published on BioPortfolio: 2016-05-12T00:38:21-0400

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