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Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)

2016-06-07 15:58:24 | BioPortfolio

Summary

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls which will compare asthmatic smooth muscle cells to non-asthmatic smooth muscle cells collected from bronchial biopsies.

Description

In an asthma exacerbation, contraction of airway smooth muscle leads to airway narrowing. Airway smooth muscle contractility is increased by the activation of the intracellular protein Rho. The current research seeks to understand the biology of regulation of Rho activation in airway smooth muscle in order to further understand the pathophysiology of asthma and to reveal potential targets for the development of molecular therapies.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Conditions

Asthma

Status

Not yet recruiting

Source

University of California, San Francisco

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-06-07T15:58:24-0400

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Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Drugs that are used to treat asthma.

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Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.

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