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Some studies suggest that regional anesthesia/analgesia may decrease the rate of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking. The purpose of this randomized controlled trial is to investigate the effect of epidural anesthesia/analgesia on the rate of recurrence/metastasis in patients undergoing lung cancer surgery.
Lung cancer is rapidly increasing and is a primary cause of cancer deaths. Surgical resection is the first line of treatment for lung cancer. However, it is unavoidable that some tumor cells will be disseminated into the blood or the lymphatic systems during surgery. The outcome depends on the balance between tumor-promoting factors and immune function of the body during the perioperative period.
Studies showed that stress response induced by surgery inhibits the cell-mediated immunity. In addition, anesthesia management during perioperative period can all affect the immune function of patients; for example, volatile anesthetics and opioids might aggravate the immunosuppression and potentially worsen long-term outcome, whereas regional anesthesia might attenuate the immunosuppression and exert protective effects. However, existing evidences are insufficient to draw conclusion in this topic.
The investigators hypothesize that regional anesthesia might improve long-term outcome in patients after lung cancer surgery, possibly by preserving postoperative immune function. The purpose of this randomized controlled trial is to investigate the effect of epidural anesthesia/analgesia on the rate of recurrence/metastasis in patients undergoing lung cancer surgery.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Combined Epi-GA/PCEA, GA/PCIA
Peking University First Hospital
Active, not recruiting
Peking University First Hospital
Published on BioPortfolio: 2016-06-15T17:53:22-0400
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Tumors or cancer of the LUNG.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
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