Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches (ESYBRECHE)
Summary
The aim of the study is to assess the efficacy and safety of Synacthène® versus placebo in the treatment of post-dural puncture syndrome in patients receiving epidural analgesia or combined spinal-epidural analgesia for labour.
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Post-dural Puncture Headache
Intervention
Tetracosactide (Synacthène®), placebo saline (0.9% NaCl)
Location
Hospices Civils de Lyon / hôpital de la Croix rousse
Lyon
France
69004
Status
Recruiting
Source
Hospices Civils de Lyon
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT02813655
- ClinicalTrials.gov processed this data on June 26, 2016
Published on BioPortfolio: 2016-06-27T20:53:21-0400
Clinical Trials
Aminophylline for Patients With Post-Dural Puncture Headache
Post-dural puncture headache (PDPH) is the most common complication of lumbar puncture. Its clinical manifestations are pain in the forehead and the occipital region, or diffuse headache. ...
Lumbar Spine Ultrasound of Patients With Previous Accidental Dural Puncture During Labour Epidural
Accidental dural puncture is a potential complication of epidural analgesia for labour and delivery. When it happens, it may cause debilitating headaches and other symptoms that prevent mo...
Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache
The objective of the study is to determine the effectiveness of Spheno-Palatine (SP) ganglion block to alleviate the pain of post-dural puncture headache (PDPH).
The Sphenopalatine Ganglion Block for Post-dural Puncture Headache
This study aims to determine the efficacy of the sphenopalatine ganglion block in the treatment of post-dural puncture headache in post-partum women at the Brigham and Women's Hospital by ...
Caffeine Versus Placebo for Spinal Headaches
Caffeine will be studied against placebo in patients with positional headache after a lumbar puncture (aka "spinal headache").
PubMed Articles
Does Bed Rest or Fluid Supplementation Prevent Post-Dural Puncture Headache?
For a drug to acquire Food and Drug Administration approval, it must significantly outperform placebo treatment. In recent years, the placebo effect seems to be increasing in neuropsychiatric conditio...
Duraplasty, a common neurosurgical intervention, involves synthetic or biological graft placement to ensure dural closure. The objective of this study is to advance our understanding of the use of dur...
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-u...
In this study, Microbial Fuel Cell (MFC) capable of treating saline starch water was developed. Sodium chloride (NaCl) concentrations ranging from 500 mM to 3000 mM were tested at the anode. Nitra...
Medical and Biotech [MESH] Definitions
Post-dural Puncture Headache
A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.
Saline Solution, Hypertonic
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Haloarcula
A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.
Halomonadaceae
A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.
Movement Disorders
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
