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Identification of Anaphylactogenic Antibodies in Peanut Allergy

2016-07-04 23:11:11 | BioPortfolio

Published on BioPortfolio: 2016-07-04T23:11:11-0400

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Early Peanut Introduction: Translation to Clinical Practice

The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step towards prevention of food allergy. However, because that finding was from a clin...

Mucosal Immunotherapy for Peanut Allergy in Young Children

Peanut allergy is known to cause severe anaphylactic reactions.The goal of this proposal is to produce a new treatment that would benefit young subjects who have recently been diagnosed wi...

Oral Immunotherapy (OIT) for Peanut Allergy

Peanut allergy is known to cause severe anaphylactic reactions.The goal of this proposal is to produce a new treatment that would benefit subjects who have peanut allergy by lowering the r...

Early Life Origins of the Food Allergy Epidemic

The purpose of this study is to determine if avoidance of peanut by children with positive allergy testing to peanut in the first 5 years of life increases the likelihood of developing a p...

Evaluating the Safety and Efficacy of Fecal Microbiota Transplant in Peanut Allergic Patients

This is a Phase I trial to evaluate the safety and efficacy of fecal microbiota transplantation (FMT) in the treatment of peanut allergy. In this research the investigators would like to l...

PubMed Articles [11040 Associated PubMed Articles listed on BioPortfolio]

Identification and analysis of peanut-specific T effector and T regulatory cells in children allergic and tolerant to peanut.

Peanut allergy is potentially life-threatening and generally persists lifelong. Recent data suggests the skin may be an important route of initial sensitization to peanut, while early oral exposure to...

Single cell profiling of peanut-responsive T cells in peanut allergic subjects reveals heterogeneous effector Th2 subsets.

The contribution of phenotypic variation of peanut-specific T cells to clinical allergy or tolerance to peanut is not well understood.

Predicting reactivity threshold in children with anaphylaxis to peanut.

Peanut allergy necessitates dietary restrictions, preferably individualised by determining reactivity threshold through an oral food challenge (OFC). However, risk of systemic reactions often preclude...

The Health and Economic Outcomes of Peanut Allergy Management Practices.

Peanut allergy is managed with strict avoidance, epinephrine carriage, and promptly treating reactions.

Peanut lipids display potential adjuvanticity by triggering a pro-inflammatory response in human keratinocytes.

Currently, the earliest cellular and molecular signals driving allergic sensitization to peanuts are not fully understood, even though peanut allergens have been studied extensively. Meanwhile, lipids...

Medical and Biotech [MESH] Definitions

A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans.

Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

Allergic reaction to peanuts that is triggered by the immune system.

Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.

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