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T follicular helper lymphocytes are involved in the pathophysiology of autoimmune diseases. In humans, an increase in the proportion of circulating follicular helper T lymphocytes is observed in systemic lupus erythematous, Sjögren syndrome. No study has yet been conducted in patients with autoimmune hemolytic anemia. In another autoimmune cytopenia, immunological thrombocytopenia pathogenesis (ITP), the investigators showed for the first time an increase in circulating TFH and splenic TFH and their implication in the activation of autoreactive B lymphocytes.
Hypothesis is that autoimmune hemolytic anemia is associated with an increase in the number and/of function of TFH, which thus participate in the hyperactivation of B lymphocytes.
The demonstration that TFH are implicated in autoimmune hemolytic anemia will rapidly lead to the use of targeted therapies to inhibit these cells. These treatments are in the clinical phase of development in other autoimmune diseases.
This study is interventional because of a lots of blood sample
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
Autoimmune Hemolytic Anemia
CHU Dijon Bourgogne
Centre Hospitalier Universitaire Dijon
Published on BioPortfolio: 2016-07-12T00:53:21-0400
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Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.
A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Hemolytic anemia due to various intrinsic defects of the erythrocyte.
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