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Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Plasma Concentration

2016-07-21 02:23:21 | BioPortfolio

Summary

In this project, the investigators aim to investigate if daily carnitine supplementation could induce TMAO productivity of vegetarian gut microbiota and through which the TMAO producers might be disclosed.

Description

Recently, plasma trimethylamine N-oxide (TMAO) level has been proved to be a strong and independent risk factor of cardiovascular disease. TMAO is formed through interaction between gut microflora and the ingested carnitine from food. Studies have shown that plasma TMAO concentration and TMAO productivity of gut microbiota in vegetarians are significantly lower than omnivores. This is probably due to a lack of carnitine in the diet of vegetarians. Therefore, it is worth investigating whether carnitine supplementation could induce TMAO productivity of human gut microbiota as well as to reveal TMAO producers from gut microflora. Therefore, the investigators plan to recruit 20 vegetarian and 10 omnivore volunteers to receive carnitine supplement for weeks, and study the change of plasma TMAO and gut microbiota. The plasma TMAO concentration will be measured by the LC-MS, and the gut microbiota composition will be analyzed by the next generation sequencing. Through bioinformatics analysis, the potential TMAO-producing bacteria might be discovered. The change of plasma TMAO level and gut microbiota composition after carnitine supplementation can provide more understanding on the relationship between carnitine supplement, TMAO and gut microflora.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Atherosclerosis

Intervention

L-carnitine

Location

National Taiwan University Hospital
Taipei
Taiwan
100

Status

Recruiting

Source

National Taiwan University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-07-21T02:23:21-0400

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Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.

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An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. EC 2.3.1.21.

Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.

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