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The impact of breastfeeding on the infant microbiome in vaginally and Cesarean delivered offspring from obese and normal weight mothers.
Design: Normal weight (NW; pre-pregnant BMI <25.0 kg/m2) and obese (Ob; pre-pregnant BMI >30.0 kg/m2) mothers between 36-38 weeks of pregnancy will be recruited from the University of Florida (UF) Health Shands Hospital and stool, blood, urine, body composition and clinical variables will be collected from mother and infant at delivery, 2-weeks, 2-months and 1-year at the UF Clinical Research Center. The study team will recruit equal samples of pregnant mothers in each the following groups (n=25 in each group): 1) NW vaginal deliveries; 2) NW C-section deliveries; 3) Ob vaginal deliveries and 4) Ob C-section deliveries. Infant body composition is the primary outcome and will be monitored via anthropometry. This proposal is requesting funds to collect human milk (HM) samples, measure bioactive compounds in human milk (HM), and test these data for association with the infant gut microbiome within the context of the longitudinal maternal-infant data described above.
Observational Model: Cohort, Time Perspective: Prospective
Not yet recruiting
University of Florida
Published on BioPortfolio: 2016-07-26T03:08:21-0400
The Pediatric Obesity Research Registry will function to collect and catalog historical and medical chart related clinical data of patients presenting with pediatric obesity and who agree ...
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BODY MASS INDEX in children (ages 2-12) and in adolescents (ages 13-18) that is grossly above the recommended cut-off for a specific age and sex. For infants less than 2 years of age, obesity is determined based on standard weight-for-length percentile measures.
Registered nurses with graduate degrees in nursing who provide care to pediatric patients who are acutely or critically ill.
A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.
The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity.
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...
Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...