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Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man

2016-07-29 04:08:21 | BioPortfolio

Summary

Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism.

Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with aromatase inhibitor, the respective effects of estradiol, testosterone or both steroids administered in a cross-over Latin squares plan on insulin sensitivity measured by the reference method of the hyperinsulinemic euglycemic clamp.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Hypogonadism

Intervention

Estradiol (Insulin sensitivity), Testosterone (Insulin sensitivity)

Location

Endocrinology Unit and Clinical Research Center Basse Normandie, University Hospital of Caen
Caen
France
14000

Status

Active, not recruiting

Source

University Hospital, Caen

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-07-29T04:08:21-0400

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