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Magnetic Resonance Spectroscopy Age of Correcting and Term Evaluation of Executive Duties at the Age of 5 Years in A Cohort of Newborn Premature Great (EPIRMEX)

2016-08-02 05:53:23 | BioPortfolio

Summary

EPIRMEX is a complementary study to the national cohort EPIPAGE 2 the INSERM Unit 953 is responsible. The objective is to study EPIRMEX at the age of 5 years corrected executive functions (EF) in children born very prematurely in relation to structural brain abnormalities in magnetic resonance imaging (MRI) (technical conventional and advanced) performed at the age of term. The current demand is expected to finance a project on a subset of the population of premature EPIRMEX subjects who had an advanced technique as magnetic resonance spectroscopy (MRS). It is a recent imaging technique for a study of the cerebral metabolism. It is based on the detection of cerebral metabolites, and the variations of their concentration to characterize different pathologies. In most cases, combinations of metabolites are informed creatine + phosphocreatine (CR), glycerophosphocholine + phosphocholine (CHO) + Nacétylaspartate Nacetylaspartylglutamate (NAA), myoinositol (INS) and lactate (LAC). In the premature newborn, the NAA / CHO ratio increases with age in all brain regions. The LAC / NAA ratio decreases significantly with age in the thalamus, basal ganglia, the corticospinal tract, and parietal white matter tends to decrease elsewhere (1-3). A number of studies show that proton spectroscopy term can predict the long-term newborn who presented an anoxic-ischemic encephalopathy (4, 5). These studies indicate that an increase in lactate and a decrease in NAA are correlated with abnormal neurological development. And decreases in NAA / CR and / or NAA / CHO ratios are predictive of motor abnormalities in children with anoxic encephalopathy presented an ischemia (6). These decreases were also measured in the basal ganglia, occipital cortex, and areas near the last. Few studies have explored the magnetic resonance spectroscopy of proton-term prediction of the future of large premature.

Description

This is a prospective cohort study on a subsample of children born prematurely (before 33 weeks of gestation (SA) otherwise included in the national cohort EPIPAGE 2 and included in epirmex and who enjoys a spectrosocpie. This research project proposed in the framework of the AORC as ancillary study EPIPAGE 2 -EPIRMEX therefore focuses on spectroIRM voluntarily at the age of term (39-41 SA), and more specifically the emergence executive functions to 5 years EPIRMEX main objective of the study. the application of our project to this tender is requested by the PACA region due to the high rate spectroIRM performed by our area (about 75%) and strong involvement of Dr. C. Gire in EPIPAGE 2 and EPIRMEX. However, only neuropsychological assessments FE 5 years testing sub-cities will be funded EPIPAGE 2. The specific aspect of our study is not funded EPIPAGE 2.

The children received conventional MRI at the age of term (39-41 SA), supplemented by specific sequences for single voxel analysis in microstructural analysis (white matter, basal ganglia and brainstem), short echo and echo time consuming. The study of the spectra will be done quantitatively by CEMEREM laboratory - UMR 6612 CNRS / Université de la Méditerranée / Division of Medical Imaging (Pr Guye).

The relevance of the project was its ability to include quality as 550 MRI were performed, including 120 MRI spectrometer can be analyzed.

These children were assessed within 2 EPIPAGE the corrected age of 2 years, 3 years (EPIRMEX) and 5 years (2 + EPIPAGE EPIRMEX). The balance sheet under 5 years in EPIRMEX is evaluating a comprehensive intellectual efficiency WPPSI III, some elements of the NEPSY and the figure of REY.

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Children Born Very Prematurely in Relation to Structural Brain Abnormalities

Intervention

an advanced technique as magnetic resonance spectroscopy (MRS)

Status

Not yet recruiting

Source

Assistance Publique Hopitaux De Marseille

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-02T05:53:23-0400

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Medical and Biotech [MESH] Definitions

A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Spectroscopy technique which measures changes in organic compounds by tracking the spectral energy of absorption of HYDROGEN atoms.

Magnetic resonance spectroscopy involving detection of changes in the resonance of carbon-13 nuclei in organic molecules.

A type of FLUORESCENCE SPECTROSCOPY using two FLUORESCENT DYES with overlapping emission and absorption spectra, which is used to indicate proximity of labeled molecules. This technique is useful for studying interactions of molecules and PROTEIN FOLDING.

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