Topics

Influence of Gender on Interaction of Propofol and Dexmedetomidine

2016-08-04 05:53:22 | BioPortfolio

Summary

The purpose of this study is to determine the effect of gender on pharmacodynamic interaction of propofol and dexmedetomidine, exploring the effect of gender on propofol unconsciousness median effective concentration with different dose dexmedetomidine.

Description

64 cases male patients were randomly divided into four groups,and 64 female patients were also randomly divided into four groups.In each group, dexmedetomidine target plasma concentration are 0,0.4,0.6,0.8 ng/ml. Dexmedetomidine administered 15 min before target controlled infusion of propofol. The propofol infusion is started to provide a target effect-site concentration of 1.0 ug/ml, and increased by 0.2 ug/ml until loss of consciousness when the effect-site concentration and target concentration are equilibrium.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Anesthesia

Intervention

0.0 ng/ml Dexmedetomidine, 0.4 ng/ml Dexmedetomidine, 0.6 ng/ml Dexmedetomidine, 0.8 ng/ml Dexmedetomidine, Propofol

Location

Guangzhou Military Region General Hospital, Department of Anesthesiology
Guangzhou
Guangdong
China
510010

Status

Recruiting

Source

Guangzhou General Hospital of Guangzhou Military Command

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-04T05:53:22-0400

Clinical Trials [1881 Associated Clinical Trials listed on BioPortfolio]

Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia

The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective ...

The Neuroprotection Effect of Dexmedetomidine

The brain protection effect of dexmedetomidine has been approved in several studies. Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of ...

Dexmedetomidine and Blood Coagulation

Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators...

Pharmacokinetic Study of Dexmedetomidine After Intra-nasal Dosing in Children

This research study is examining the absorption of the sedative dexmedetomidine (DEX) in the blood when given by nasal spray. The study will help us determine the best dosing amount for ch...

Dexmedetomidine Reduces Emergence Delirium in Children Undergoing Tonsillectomy With Propofol Anesthesia

Dexmedetomidine (DEX) is safe and effective in reducing ED following sevoflurane anesthesia. The investigators intend to study the efficacy of DEX in reducing ED in children undergoing ton...

PubMed Articles [1067 Associated PubMed Articles listed on BioPortfolio]

Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial.

In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized ...

Dexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study.

Dexmedetomidine provides smooth and hemodynamically stable emergence at the expense of hypotension, delayed recovery, and sedation. We investigated the optimal dose of dexmedetomidine for prevention o...

Dexmedetomidine Infusion Overdose during Anaesthesia: A Case Report.

A 12 kg infant was given intravenous dexmedetomidine 0.2 µg.kg .min as an adjunct for general anaesthesia. The 60-fold increase in dexmedetomidine infusion rate caused a biphasic response with initia...

Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.

Dexmedetomidine is increasingly used off-label in infants and children with cardiac disease during cardiopulmonary bypass (CPB) and in the postoperative period. Despite its frequent use, optimal dosin...

Comparison of the ED50 of intrathecal hyperbaric ropivacaine co-administered with or without intrathecal dexmedetomidine for cesarean section: A prospective, double-blinded, randomized dose-response trial using up-down sequential allocation method.

Studies have showed that intrathecal dexmedetomidine as supplements to local anesthetics can improve the quality of the spinal anesthesia and reduce the local anesthetic requirement of spinal anesthes...

Medical and Biotech [MESH] Definitions

A selective inhibitor of RECEPTORS, ADRENERGIC ALPHA-2 that has analgesic and sedative properties. MEDETOMIDINE is the other racemic form.

An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE.

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.

Abnormally slow pace of regaining CONSCIOUSNESS after general anesthesia (ANESTHESIA, GENERAL) usually given during surgical procedures. This condition is characterized by persistent somnolence.

More From BioPortfolio on "Influence of Gender on Interaction of Propofol and Dexmedetomidine"

Quick Search

Relevant Topics

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Anesthesiology
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...


Searches Linking to this Trial