Influence of Gender on Interaction of Propofol and Dexmedetomidine

2016-08-04 05:53:22 | BioPortfolio


The purpose of this study is to determine the effect of gender on pharmacodynamic interaction of propofol and dexmedetomidine, exploring the effect of gender on propofol unconsciousness median effective concentration with different dose dexmedetomidine.


64 cases male patients were randomly divided into four groups,and 64 female patients were also randomly divided into four groups.In each group, dexmedetomidine target plasma concentration are 0,0.4,0.6,0.8 ng/ml. Dexmedetomidine administered 15 min before target controlled infusion of propofol. The propofol infusion is started to provide a target effect-site concentration of 1.0 ug/ml, and increased by 0.2 ug/ml until loss of consciousness when the effect-site concentration and target concentration are equilibrium.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment




0.0 ng/ml Dexmedetomidine, 0.4 ng/ml Dexmedetomidine, 0.6 ng/ml Dexmedetomidine, 0.8 ng/ml Dexmedetomidine, Propofol


Guangzhou Military Region General Hospital, Department of Anesthesiology




Guangzhou General Hospital of Guangzhou Military Command

Results (where available)

View Results


Published on BioPortfolio: 2016-08-04T05:53:22-0400

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