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A Study of HMPL-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms

2016-08-09 08:42:29 | BioPortfolio

Published on BioPortfolio: 2016-08-09T08:42:29-0400

Clinical Trials [281 Associated Clinical Trials listed on BioPortfolio]

A Study of HMPL-689 in Healthy Volunteers

The purpose of this study is to evaluate the safety and tolerability of a single dose of HMPL-689 in healthy volunteers To determine the pharmacokinetic profile of single oral doses of HMP...

A Study of HMPL-523 in Relapsed or Refractory B-cell Non-Hodgkin's Lymphomas or Chronic Lymphocytic Leukemia

The purpose of this study is to evaluate the safety and tolerability of HMPL-523 administered to patients with relapsed or refractory B-cell Non-Hodgkin's Lymphomas or Chronic Lymphocytic ...

A Study of BGB-A317 in Patients With Relapsed or Refractory Mature T- and NK- Neoplasms

This is a multi-center, prospective, non-randomized, open-label, Phase 2 clinical study to evaluate the safety and efficacy of BGB-A317 in patients with relapsed or refractory mature T- an...

A Study of the Safety, Tolerability and Pharmacokinetics of HMPL-523

The primary objective of this study is to assess the safety and tolerability of a single dose of 5, 20, 50, 100, 200 and 300 mg HMPL-523 in Part A, followed by multiple doses of selected s...

A Mass Balance Study to Investigate the Absorption, Metabolism, and Excretion Of [14C] Fruquintinib

This will be an open-label, single-center study to evaluate pharmacokinetics and safety of HMPL-013 in approximately 6 healthy male subjects receiving a single oral 5mg dose of HMPL-013 co...

PubMed Articles [16551 Associated PubMed Articles listed on BioPortfolio]

Flow Cytometry of B-Cell Neoplasms.

Flow cytometric evaluation is considered a standard ancillary study for the diagnosis of most B-cell lymphoproliferative disorders. Establishing a neoplastic B-cell population depends on identificatio...

Quantitative assessment of informative immunophenotypic markers increases the diagnostic value of immunophenotyping in mature CD5-positive B-cell neoplasms.

The data on the clinical utility of the quantitative assessment of immunophenotypes in distinguishing mature CD5-positive B-cell neoplasms is limited. The study aim was to assess the diagnostic value ...

Flow Cytometry of T cells and T-cell Neoplasms.

Flow cytometry is ideally suited for the immunophenotypic analysis of T-cell neoplasia. This article covers the spectrum of flow cytometric findings associated with frequently encountered benign and n...

Cutaneous T-Cell Lymphoma, a Novel Manifestation of PDGFRA-Rearranged Neoplasm.

Patients with PDGFRA-rearranged hematopoietic neoplasms typically present with chronic eosinophilic leukemia and rarely with acute myeloid leukemia or T-lymphoblastic lymphoma. However, mature T-cell ...

Flow Cytometric Assessment of Chronic Myeloid Neoplasms.

Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no...

Medical and Biotech [MESH] Definitions

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.

Neoplasms composed of squamous cells of the epithelium. The concept does not refer to neoplasms located in tissue composed of squamous elements.

Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)

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