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PD-1 Knockout Engineered T Cells for Muscle-invasive Bladder Cancer

2016-08-12 08:53:21 | BioPortfolio

Summary

This study will evaluate the safety of PD-1 knockout engineered T cells in treating metastatic advanced bladder cancer. Blood samples will also be collected for research purposes.

Description

This is a dose-escalation study of ex-vivo knocked-out, expanded, and selected PD-1 knockout-T cells from autologous origin. Patients are assigned to 1 of 3 treatment groups to determine the maximal tolerant dose. After the lower number of cycles are considered tolerant, an arm of the next higher number of cycles will be open to next patients. Biomarkers and immunological markers are collected and analyzed as well.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Invasive Bladder Cancer Stage IV

Intervention

PD-1 Knockout T Cells, Cyclophosphamide, IL-2

Location

Department of Urology Peking University First Hospital
Beijing
Beijing
China
100034

Status

Not yet recruiting

Source

Peking University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-12T08:53:21-0400

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