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To obtain olfactory bulbs from brain stem dead patients who undergo organ donation.
1. Optimisation of olfactory bulb collection and olfactory ensheathing cell culture and storage.
3. In future studies, the olfactory ensheathing cells may be injected into patients with spinal cord injuries.
Spinal cord injury is a devastating condition. To date there is no treatment to improve outcome. There is a limited regenerative capacity of the central nervous system, such that damaged neurons and severed axons are not replaced.
A substantial body of evidence suggests that olfactory ensheathing cells obtained from olfactory bulbs facilitate neuronal regeneration in rodents and humans with spinal cord injury.
Investigators will study heterologous olfactory ensheathing cells as a treatment for spinal cord injury. Investigators propose collecting human olfactory ensheathing cells from brain stem dead organ donors.
In PHASE 1, the olfactory ensheathing cells will be cultured and their properties will be investigated to optimise collection and storage conditions.
In PHASE 2, olfactory ensheathing cells will be transplanted into patients with spinal cord injury.
Spinal Cord Injury
No intervention is proposed
Not yet recruiting
St George's, University of London
Published on BioPortfolio: 2016-08-19T11:25:15-0400
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Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.
Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
Ischemia or infarction of the spinal cord in the distribution of the anterior spinal artery, which supplies the ventral two-thirds of the spinal cord. This condition is usually associated with ATHEROSCLEROSIS of the aorta and may result from dissection of an AORTIC ANEURYSM or rarely dissection of the anterior spinal artery. Clinical features include weakness and loss of pain and temperature sensation below the level of injury, with relative sparing of position and vibratory sensation. (From Adams et al., Principles of Neurology, 6th ed, pp1249-50)
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