Prediction and Management of Delayed Graft Function Based on Donor Criteria and LifePort Platform

2016-08-25 12:23:21 | BioPortfolio


This is a prospective cohort study:

1. First step: to establish a new scoring system for predication of delayed graft function(DGF) following kidney transplantation based on previous and new study data. The new scoring system is comprised of two parts: Xi'an Criteria of donor scoring system and kidney evaluation System based on Lifeport platform ).

2. Second step: validate the new scoring system through prospective cohort study in our transplantation center and modify the scoring system if needed. Recruiting 300 patients, follow up at day 3, week 1, month1, month3, month 6 and month12. Patients will be followed for Cr30cl, DGF,primary non-function (PNF), acute rejection (AR), graft survival and patient survival

3. Step 3: Further validate the new scoring system in six other transplantation centers and developing a software in the end. Recruiting 300 patients, follow up at day 3, week 1, month1, month3, month 6 and month12. Patients will be followed for Cr30cl, DGF, PGF, AR, graft survival and patient survival


Subjects are enrolled to collect the data of donors and recipients. We also collect the data of recipients or donated organs as following: physiological and biochemical indexes, machine perfusion parameters, and the other factors effected on renal transplant outcomes. A Cox proportional hazards model and multiple linear regression analysis will be applied to examine the correlation among the univariates and multivariate. Based on the above analysis to improve the new scoring system, LifePort work platform evaluation system and donor kidney quality evaluation system. Then, a multicenter clinical trial will be started to improve and verify the new scoring system. Finally, a donor kidney evaluation APP will be developed based on the scoring system and the database of clinical trials. An applicaiotion (APP) will be popularized the national transplant surgeons.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Delayed Graft Function


Machine perfusion


First Affiliated Hospital Xi'an Jiaotong University




First Affiliated Hospital Xi'an Jiaotong University

Results (where available)

View Results


Published on BioPortfolio: 2016-08-25T12:23:21-0400

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PubMed Articles [11228 Associated PubMed Articles listed on BioPortfolio]

Hypothermic Machine Perfusion Versus Static Cold Storage in Deceased Donor Kidney Transplantation: a systematic review and meta-analysis of Randomized Controlled Trials.

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Medical and Biotech [MESH] Definitions

General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

Apparatus that provides mechanical circulatory support during open-heart surgery, by passing the heart to facilitate surgery on the organ. The basic function of the machine is to oxygenate the body's venous supply of blood and then pump it back into the arterial system. The machine also provides intracardiac suction, filtration, and temperature control. Some of the more important components of these machines include pumps, oxygenators, temperature regulators, and filters. (UMDNS, 1999)

The immune responses of a host to a graft. A specific response is GRAFT REJECTION.

An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.

A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.

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Chronic kidney disease (CKD), also known as chronic renal disease, is a progressive loss in renal function over a period of months or years. The symptoms of worsening kidney function are non-specific, and might include feeling generally unwell and experi...

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