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Prediction and Management of Delayed Graft Function Based on Donor Criteria and LifePort Platform

2016-08-25 12:23:21 | BioPortfolio

Summary

This is a prospective cohort study:

1. First step: to establish a new scoring system for predication of delayed graft function(DGF) following kidney transplantation based on previous and new study data. The new scoring system is comprised of two parts: Xi'an Criteria of donor scoring system and kidney evaluation System based on Lifeport platform ).

2. Second step: validate the new scoring system through prospective cohort study in our transplantation center and modify the scoring system if needed. Recruiting 300 patients, follow up at day 3, week 1, month1, month3, month 6 and month12. Patients will be followed for Cr30cl, DGF,primary non-function (PNF), acute rejection (AR), graft survival and patient survival

3. Step 3: Further validate the new scoring system in six other transplantation centers and developing a software in the end. Recruiting 300 patients, follow up at day 3, week 1, month1, month3, month 6 and month12. Patients will be followed for Cr30cl, DGF, PGF, AR, graft survival and patient survival

Description

Subjects are enrolled to collect the data of donors and recipients. We also collect the data of recipients or donated organs as following: physiological and biochemical indexes, machine perfusion parameters, and the other factors effected on renal transplant outcomes. A Cox proportional hazards model and multiple linear regression analysis will be applied to examine the correlation among the univariates and multivariate. Based on the above analysis to improve the new scoring system, LifePort work platform evaluation system and donor kidney quality evaluation system. Then, a multicenter clinical trial will be started to improve and verify the new scoring system. Finally, a donor kidney evaluation APP will be developed based on the scoring system and the database of clinical trials. An applicaiotion (APP) will be popularized the national transplant surgeons.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Delayed Graft Function

Intervention

Machine perfusion

Location

First Affiliated Hospital Xi'an Jiaotong University
Xi'an
Shaanxi
China
710061

Status

Recruiting

Source

First Affiliated Hospital Xi'an Jiaotong University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-25T12:23:21-0400

Clinical Trials [1350 Associated Clinical Trials listed on BioPortfolio]

Pulsatile Perfusion Preservation in Kidney Transplantation From Expanded Criteria Donors

Our hypothesis is that the Waters Medical® pulsatile perfusion machine (RM 3) is a way to improve delayed graft function (DGF) in marginal grafts, and some perfusion profiles (flow, press...

The Feasibility and Safety of Normothermic ex Vivo Kidney Perfusion

Kidney transplantation is the treatment of choice for end-stage kidney failure, but access to transplantation is limited by a severe shortage of donor organs. Although the use of kidneys f...

Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine

The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidn...

Clinical Impact of Hypothermic Machine Perfusion in Renal Transplant Recipients

This is a multi-centers prospective, randomized, controlled trial. This trial will investigate the clinical outcome of kidney transplant recipients whose kidneys are under two different fo...

QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant

The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD).

PubMed Articles [10980 Associated PubMed Articles listed on BioPortfolio]

Machine perfusion and long-term kidney transplant recipient outcomes across allograft risk strata.

The use of machine perfusion (MP) in kidney transplantation lowers delayed graft function (DGF) and improves 1-year graft survival in some, but not all, grafts. These associations have not been explor...

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study.

This study focused on the value of quantitatively analyzed and qualitatively graded renal scintigraphy in relation to the expected duration of delayed graft function after kidney transplantation. A mo...

Predicition models for delayed graft function: external validation on The Dutch Prospective Renal Transplantation Registry.

Delayed graft function (DGF) is a common complication after kidney transplantation in the era of accepting an equal number of brain- and circulatory-death donor kidneys in the Netherlands. To identify...

Hypothermic Machine Perfusion in Liver Transplantation.

A finite supply of donor organs has led many transplant centers to accept marginal liver allografts with increasing frequency. These allografts may be at higher risk of primary non-function, early all...

Preliminary experience of sequential use of normothermic and hypothermic oxygenated perfusion for DCD kidney with warm ischemia time over the conventional criteria.

Donation after circulatory death (DCD) is a potential source of reducing organ demand. In Italy, DCD requires a 20 minutes no-touch period, that prolongs warm ischemia and increases delayed graft func...

Medical and Biotech [MESH] Definitions

General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

Apparatus that provides mechanical circulatory support during open-heart surgery, by passing the heart to facilitate surgery on the organ. The basic function of the machine is to oxygenate the body's venous supply of blood and then pump it back into the arterial system. The machine also provides intracardiac suction, filtration, and temperature control. Some of the more important components of these machines include pumps, oxygenators, temperature regulators, and filters. (UMDNS, 1999)

The immune responses of a host to a graft. A specific response is GRAFT REJECTION.

An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.

A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.

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