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Vascular EffectS of regUlar Cigarettes Versus electronIc Cigarette USe

2016-08-26 12:38:22 | BioPortfolio

Summary

The purpose of this study is to assess the effects of electronic cigarettes-nicotine and electronic cigarette-nicotine free on endothelial function as compared to traditional cigarettes.

Participants will be randomized to one of three groups in a 1:1:1 fashion. The groups will be:

1. Continue with tobacco cigarettes

2. Switch to electronic cigarettes containing nicotine plus flavor

3. Switch to electronic cigarettes containing flavor alone Treatment period will be 28 days

Description

Electronic cigarettes (EC) are gaining popularity as an alternative to Traditional Cigarettes (TC). Despite not containing all the harmful substances seen in TC, EC are known to contain impurities that may have a detrimental impact on human health. The effects of ECs compared with TC on vascular function, inflammation and oxidative stress are unknown. It is increasingly recognised that nicotine itself has significant atherothrombotic effects. Therefore, clinicians are unable to confidently recommend ECs as a less risky alternative to TC.

Hypothesis: Endothelial function will be improved on EC compared to TC when measured by flow mediated dilatation (FMD).

Potential benefit: This study will provide further information on the potential use these devices and the risks and/or benefits associated with them, specifically in relation to vascular health.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)

Conditions

Vascular Diseases

Intervention

electronic cigarette + 16mg nicotine & flavor, electronic cigarette + 0mg nicotine & flavor, Tobacco cigarette

Location

University of Dundee
Dundee
Tayside
United Kingdom
DD1 9SY

Status

Not yet recruiting

Source

University of Dundee

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-26T12:38:22-0400

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Medical and Biotech [MESH] Definitions

Electronic devices that are designed to provide NICOTINE in the form of an inhaled aerosol. They typically are made in the shape of CIGARETTES in order to simulate the experience of CIGARETTE SMOKING.

SMOKING vapors produced from ELECTRONIC NICOTINE DELIVERY SYSTEMS.

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Chewing gum which contains NICOTINE.

Electronic implements worn on the body as an implant or as an accessory. Examples include wearable diagnostic devices, wearable ACTIVITY TRACKERS, wearable INFUSION PUMPS, wearable computing devices, SENSORY AIDS, and electronic pest repellents.

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