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Rifaximin Modify the Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD)

2016-08-31 15:23:21 | BioPortfolio

Summary

In Non-alcoholic fatty (NAFLD) liver disease patients, the investigators hypothesized that rifaximin might act on Gram-negative bacteria and IBO thereby inhibiting LPS-mediated proinflammatory cytokine production. This work evaluates the efficacy of 6 months administration of rifaximin in NAFLD patients.

Description

The investigators aimed to study the effect of rifaximin on NAFLD. 126 patients with biopsy-proven NAFLD [42 steatosis, 84 non-alcoholic steatohepatitis (NASH)] were enrolled in this open-label, prospective, multicentric cohort study. BMI, AST, ALT, gamma glutamyl transferase (γ-GGT), lipid profile, homeostatic model assessment (HOMA), serum endotoxin, Toll-like receptor 4 (TlR4), interleukin-6 (IL-6), IL-10, tumor necrosis factor-α (TNF-α) and cytokeratin-18 (CK-18) levels were measured before and after a 6 month administration of rifaximin (1100-1200 mg/day).

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Non-alcoholic Fatty Liver Disease

Intervention

Rifaximin

Location

Nasser H Mousa,MD,mousa_medic@yahoo.com. +201227029213
Mansoura
Egypt

Status

Completed

Source

Mansoura University

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-08-31T15:23:21-0400

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Medical and Biotech [MESH] Definitions

Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.

Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.

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Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

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