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Pre-emptive Immunomodulation After Allogeneic Stem Cell Transplantation in AML

2016-09-06 16:08:21 | BioPortfolio

Summary

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is now an effective treatment of Acute Myeloid Leukemia (AML). After allo-HSCT, relapses are the major cause of mortality and occur in about 30% of cases. The occurrence of relapses is important during the first three months post-allogeneic transplant, then gradually decreases during the first year post-allograft and then becomes weaker. After relapse, therapeutic options include the reduction of immunosuppression, the administration of donor lymphocytes (DLI), chemotherapy or a new transplant. The performance is influenced by the early introduction of treatment whose effectiveness is related to the importance of tumor burden. Immunomodulation of preemptive strategies have recently been established by decreasing immunosuppression and achieve DLIs in patients with a high risk of relapse, before the occurrence of relapse.

The aim of this study is to evaluate the incidence of relapse following the recommendations of post-allogeneic transplant immunomodulation of the French society of bone marrow transplantation.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

AML

Intervention

immunomodulation

Location

University Hospital
Caen
France
14000

Status

Recruiting

Source

University Hospital, Caen

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-06T16:08:21-0400

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