KERatoconus and Metalloproteinases InvesTigation

2016-09-07 16:23:21 | BioPortfolio


Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

Study Design

Time Perspective: Cross-Sectional




immuno-histo-chemical analysis


Not yet recruiting


Fondation Ophtalmologique Adolphe de Rothschild

Results (where available)

View Results


Published on BioPortfolio: 2016-09-07T16:23:21-0400

Clinical Trials [619 Associated Clinical Trials listed on BioPortfolio]

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The main purpose of this study is to determine new diagnostic criteria for an eye disease called keratoconus.

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Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus

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A retrospective study has shown the association between the inflammatory bowel diseases (IBD) and the presence of a keratoconus. This new study will measure the prevalence of keratoconus a...

Familial Analysis of Keratoconus Risk

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PubMed Articles [18455 Associated PubMed Articles listed on BioPortfolio]

Evaluation of corneal biomechanics in keratoconus using dynamic ultra-high-speed Scheimpflug measurements.

The in vivo analysis of corneal biomechanics in patients with keratoconus is especially of interest with respect to diagnosis, follow-up and monitoring of the disease.

Survival Analysis of Corneal Densitometry After Collagen Cross-Linking for Progressive Keratoconus.

To evaluate the history of densitometric data in patients with keratoconus undergoing corneal cross-linking.

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To determine optimal objective, machine-derived variables and variable combinations from Scheimpflug and spectral domain (SD) OCT imaging to distinguish the clinically unaffected eye in patients with ...

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Medical and Biotech [MESH] Definitions

A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

A system of safety management (abbreviated HACCP) applied mainly to the food industry. It involves the analysis and control of biological, chemical, and physical hazards, from raw material production, procurement and handling, to manufacturing, distribution and consumption of finished products.

The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.

Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.

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Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...

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