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The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex

2016-09-07 16:23:21 | BioPortfolio

Summary

In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Conditions

Healthy

Intervention

50g glucose, 25g fructose, 220mg acesulfame-K, 250mL tap water

Status

Completed

Source

Universitaire Ziekenhuizen Leuven

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-07T16:23:21-0400

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An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)

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A hexose transporter that mediates FRUCTOSE transport in SKELETAL MUSCLE and ADIPOCYTES and is responsible for luminal uptake of dietary fructose in the SMALL INTESTINE.

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