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Infant Microbiome in Diaper Rash

2016-09-08 16:53:21 | BioPortfolio

Summary

The objective of this study is to evaluate the microbiome composition of infant's (9-12 month) skin experiencing diaper rash in order to determine if the onset and severity of erythema associated with diaper rash is influenced by the type of bacteria colonizing the skin.

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Conditions

Diaper Rash

Location

Midwest Children's Health Research Institute
Lincoln
Nebraska
United States
68522

Status

Not yet recruiting

Source

Kimberly-Clark Corporation

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-08T16:53:21-0400

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Premature Pubarche due to Exogenous Testosterone Gel or Intense Diaper Rash Prevention Cream Use: A Case Series.

Premature pubarche is associated with conditions such as virilizing congenital adrenal hyperplasia, androgen-secreting tumors, and exogenous exposure to androgen products. We describe the clinical and...

Pruritic rash on chest and back.

Was a recent change in diet to blame for this patient's rash?

Urine collection methods for non-toilet-trained children in biological monitoring studies: validation of a disposable diaper for characterization of tebuconazole exposure.

Young children differ from adults in their exposure and susceptibility to environmental chemicals (e.g. pesticides) because of various factors such as behavior, diet and physiology. Their heightened v...

Persistent erythematous papulonodular rash.

The rash on our patient's abdomen was not itchy or painful, but it had persisted for more than a year and continued to spread. A biopsy confirmed our suspicions.

Photo Rounds: Rapid-onset rash in child.

Our patient's pruritic rash was spreading throughout his trunk and arms. An acute infection 10 days earlier shed light on the diagnosis.

Medical and Biotech [MESH] Definitions

A type of irritant dermatitis localized to the area in contact with a diaper and occurring most often as a reaction to prolonged contact with urine, feces, or retained soap or detergent.

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

Infection with group A streptococci that is characterized by tonsillitis and pharyngitis. An erythematous rash is commonly present.

An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.

Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s).

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