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This prospective, non-therapeutic study will determine whether a novel imaging technique can identify presumptive tumour associated macrophages (TAMs) in patients with ocular tumours.
In this study, we will modify the standard angiography protocol by having patients return twice in the week following angiography for additional photographs. Photographs will be obtained 2-7 days after angiography, but without further injection of dye. This technique contrasts with normal angiography in which photographs are taken during the transit phase of dye circulation and in the minutes thereafter. Of note, both the dye and the cameras used for its detection have been approved for clinical use for several decades and are routinely used in the evaluation of patients with ocular tumours.
We will evaluate 5 groups:
1. Choroidal nevus (low-risk features): requires distinction from melanoma through diagnostic testing
2. Choroidal indeterminate melanocytic lesion (high-risk features): requires diagnostic testing for identification and distinction from nevus and melanoma
3. Choroidal melanoma: requires confirmation of diagnosis and evaluation for potential metatstases
4. Suspected metastatic tumour (ie, primary tumour elsewhere): requires identification of primary tumour
5. Locally treated ocular tumours: requires followup to evaluate response to treatment and potential change or repeat therapy
Observational Model: Cohort, Time Perspective: Prospective
St Michael's Hospital
St. Michael's Hospital, Toronto
Published on BioPortfolio: 2016-09-21T20:23:22-0400
This study evaluates treatment with combination versus monotherapy for patients with metastatic ocular melanoma.
Patients diagnosed with ocular melanoma consent to participate in the study. Combined PET/CT scans of the whole body are performed at baseline, three months later, and six months after th...
RATIONALE: Interferon beta may interfere with the growth of tumor cells. PURPOSE: This phase II trial is studying how well interferon beta works in treating patients with metastatic cutan...
The scope of the trial is to determinate the anti-tumoral activity of imatinib in metastatic ocular melanoma patients.
Up to half of patients with ocular melanoma (also called iris, choroidal or uveal melanoma) develop metastasis. We have found that certain molecular features of the eye tumor can be detect...
We sought to formally compare Collaborative Ocular Melanoma Study (COMS) and similar-shaped (circular) eye physics (EP) plaques dosimetrically by examining both tumor coverage and critical structure d...
To evaluate the benefit of adding CT imaging to the simulation process of clip-based proton therapy of ocular melanomas. Methods: For thirty ocular melanoma cases, the clip position in the eye mo...
The purpose of this study is to examine the melanocortin-1 receptor (MC1R) targeting and specificity of 203Pb-DOTA-GGNle-CycMSHhex in melanoma cells and tumors to facilitate its potential therapeutic ...
Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examin...
To explore risk factors for choroidal nevus transformation into melanoma using multimodal imaging and review current treatment options.
An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions.
The dioptric adjustment of the EYE (to attain maximal sharpness of retinal imagery for an object of regard) referring to the ability, to the mechanism, or to the process. Ocular accommodation is the effecting of refractive changes by changes in the shape of the CRYSTALLINE LENS. Loosely, it refers to ocular adjustments for VISION, OCULAR at various distances. (Cline et al., Dictionary of Visual Science, 4th ed)
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...
Melanoma is a highly malignant tumor of melanin-forming cells (melanocytes) There are most commonly found in the skin (resulting from sunlight exposure), but also in the eyes and mucous membranes. Metastasis to other regions of the body is also common....
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...