Advertisement

Topics

Tissue Engineering Conjunctiva for the Treatment of Pterygium and Atretoblepharia

2016-09-22 20:53:26 | BioPortfolio

Summary

The purpose of this study is to determine whether tissue engineering conjunctiva is effective in the treatment of pterygium and atretoblepharia.

Description

The most important area for research on the pterygium are the recurrence occurred after operation. Now the best way to prevent the recurrence is autologous conjunctival stem cell transplantation, but this way of operation can cause lack of conjunctiva and conjunctival scar, even may effect the later glaucoma surgery. For the atretoblepharia patients, amniotic membrane transplantation and autologous oral mucosa transplantation can not make effect to alleviate it. In this pilot project, investigators would like to study the effect of tissue engineering conjunctiva transplantation in the treatment of pterygium and tissue engineering conjunctiva transplantation combined with conjunctiva sac formation for the treatment of atretoblepharia. This will allow us to determine if useful data can be obtained, and if so, lead to further studies in various conjunctiva loss caused by trauma, infections, and so on.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Pterygium

Intervention

Tissue engineering conjunctiva transplantation

Status

Not yet recruiting

Source

Shandong Eye Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-09-22T20:53:26-0400

Clinical Trials [1459 Associated Clinical Trials listed on BioPortfolio]

Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery

Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. It is a progressive disease that may lead to visual impairment in advanced stages, as well as restriction of ...

Subconjunctival Injection of Triamcinolone Acetonide and Limited Peritomy During Pterygium Excision

Pterygium is characterized by encroachment of a fleshy fibrovascular tissue from the bulbar conjunctiva on to the cornea. Although previously thought to be a solely degenerative disease, ...

The Corneal and Conjunctiva Sensation Before and After Pterygium Surgeries

The purpose of this current study is to examine the sensation of the corneal and conjunctiva sensation before and after pterygium surgeries by Cochet bonnet esthesiometer and to examine ep...

A Study of the Response to AG-86893 in Patients With Pterygium Hyperemia

A pterygium is a wing-shaped, benign tissue growth which forms on the surface of the conjunctiva and grows towards the cornea. It can eventually lead to vision impairment. The precise caus...

Outpatient Performed Pterygium Surgery Study

This is a randomized controlled trial of postoperative bevacizumab or 5-fluorouracil subconjunctival injections vs placebo for the recurrence of pterygia after excision using conjunctival ...

PubMed Articles [10421 Associated PubMed Articles listed on BioPortfolio]

Head inversion technique to restore physiological conjunctival structure for surgical treatment of primary pterygium.

We describe a new surgical technique to treat primary pterygium, the head inversion technique, with its surgical outcomes. Seventy-five eyes of 75 consecutive patients with primary pterygium undergoin...

Recent advances in stem cell therapeutics and tissue engineering strategies.

Tissue regeneration includes delivering specific types of cells or cell products to injured tissues or organs for restoration of tissue and organ function. Stem cell therapy has drawn considerable att...

A novel role for CRIM1 in the corneal response to UV and pterygium development.

Pterygium is a pathological proliferative condition of the ocular surface, characterised by formation of a highly vascularised, fibrous tissue arising from the limbus that invades the central cornea l...

Optical Coherence Tomography Angiography for Evaluation of Reperfusion following Pterygium Surgery.

To describe the use of optical coherence tomography angiography (OCTA) to quantitatively monitor the conjunctival graft revascularization after pterygium excision and conjunctival autograft (CAG) tran...

Increased Expressions of ICAM-2 and ICAM-3 in Pterygium.

Pterygium, one of the most common ocular surface diseases, is characterized by inflammatory infiltrates, proliferation, angiogenesis, fibrosis, and extracellular matrix breakdown. The objective of thi...

Medical and Biotech [MESH] Definitions

An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)

Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.

Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.

A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.

More From BioPortfolio on "Tissue Engineering Conjunctiva for the Treatment of Pterygium and Atretoblepharia"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Stem Cells
Track and monitor developments in stem cell research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry.  BioPort...

Transplantation
Organ transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative ...


Searches Linking to this Trial