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A Study of MCLA-128 in Patients With Solid Tumors

2016-09-25 21:49:16 | BioPortfolio

Published on BioPortfolio: 2016-09-25T21:49:16-0400

Clinical Trials [2016 Associated Clinical Trials listed on BioPortfolio]

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

This is a Phase I, open-label, multi-center, multi-national, dose escalation, single agent study to determine the recommended Phase II dose (RP2D) of MCLA-158 in metastatic colorectal canc...

A Phase 1, Multinational Study of MCLA-117 in Acute Myelogenous Leukemia

This is a First-in-Human, single arm, open-label, multi-national study designed to determine the safety, tolerability and preliminary efficacy of MCLA 117.

MCLA-128 With Trastuzumab/Chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer

A Phase 2, open-label, multicenter international study will be performed to evaluate the efficacy of MCLA-128-based combinations. Three combination treatments will be evaluated, two in Coh...

Combination of Anti-PD-L1 and CIK Immunotherapy for Recurrent Solid Tumor

The aim of this study is the safety and efficacy of anti-PD-L1 plus CIK immunotherapy to multiple solid tumors.

Phase I Trial of Intratumoral Administration of Recombinant Vesicular Stomatitis Virus in Patients With Refractory Solid Tumors

This is a Phase 1 study designed to determine the maximum tolerated dose (MTD) and toxicity of intratumoral administration of VSV-IFNβ-NIS in patients with refractory advanced/metastatic ...

PubMed Articles [5180 Associated PubMed Articles listed on BioPortfolio]

Robotic-assisted, spleen-preserving distal pancreatectomy for a solid pseudopapillary tumour in a pediatric patient: a case report and review of the literature.

Solid pseudopapillary tumour is a rare carcinoma of the pancreas with low-grade malignant potential that typically presents in females in their third decade. The tumour most commonly occurs in the tai...

Clinical characteristics and preliminary morphological observation of 47 cases of primary anorectal malignant melanomas.

The clinical data and paraffin-embedded samples of 47 cases of primary anorectal malignant melanomas (ARMMs) detected from 2004 to 2017 were collected to investigate the clinicopathological characteri...

Prognostic ability of new T1 descriptors in the tumour, node and metastasis classification of surgically treated non-small-cell lung cancer.

In the tumour, node and metastasis (TNM) classification (8th edition) of non-small-cell lung cancer, T (tumour size) is determined solely according to the size of the solid component determined using ...

Giant adrenal pseudocyst: A rare diagnosis.

We present a rare case of giant adrenal pseudocyst as a cause of right upper quadrant (RUQ) pain and highlight the typical multimodality imaging features. The case demonstrates the imaging features as...

Safety, efficacy and survival of patients with primary malignant brain tumours (PMBT) in phase I (Ph1) trials: the 12-year Royal Marsden experience.

Primary malignant brain tumours (PMBT) constitute less than 2% of all malignancies and carry a dismal prognosis. Treatment options at relapse are limited. First-in-human solid tumour studies have hist...

Medical and Biotech [MESH] Definitions

A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)

Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Garbage, refuse, or sludge, or other discarded materials from a wastewater treatment plant, water supply treatment plant, and air pollution control facility that include solid, semi-solid, or contained material. It does not include materials dissolved in domestic sewage, irrigation return flows, or industrial discharges.

Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.

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