Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU)

2016-09-26 22:23:21 | BioPortfolio


MRI-guided high intensity focused ultrasound (MRI-HIFU) has been proven to be a safe and effective method in treating uterine fibroids and also adenomyosis. However, systematic studies on the effect of this treatment on factors affecting fertility are still lacking. Also quite little is known about body's systemic response to MRI-HIFU. Thus the aim of this study is to obtain more information on the systemic response of the body to the HIFU-treatment when treating non-malignant disease as well as to study the effect of MRI-HIFU on factors affecting fertility. Women with symptomatic uterine fibroids or adenomyosis and with no wish for further pregnancies will be selected for this study and treated using MRI-HIFU. The severity of symptoms will be assessed with UFS-QoL and the same questionnaire will also be used in follow-up 3, 6 and 12 months after treatment. Blood, urine and endometrium samples will be collected pre- and postoperatively and during follow-up 3, 6 and 12 months after the treatment. From these samples detailed analysis of the immunological, inflammatory and hormonal response will be performed. As this is the first study in Finland of treating uterine fibroids and adenomyosis using MRI-HIFU, also a report about the efficacy of the MRI-HIFU in treating the uterine disorders will be published, and a key tool in assessing the treatment outcome would be the UFS-QoL questionnaire.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Uterine Fibroids




Turku University Hospital




Turku University Hospital

Results (where available)

View Results


Published on BioPortfolio: 2016-09-26T22:23:21-0400

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Medical and Biotech [MESH] Definitions

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Pathological processes of the UTERINE CERVIX.

Loss or destruction of the epithelial lining of the UTERINE CERVIX.

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