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GALIG Gene Expression in Parkinson's Disease

2016-10-05 00:23:21 | BioPortfolio

Summary

Parkinson's disease (PD) is the most frequent neurodegenerative disorder after Alzheimer's disease. It is characterized by motor symptoms (rigidity, tremor, slowness of movements), and non-motor symptoms (neuropsychological, psychiatric, pain ...). Neuronal death initiates in the brainstem and extends progressively through the entire cortex. The processes leading to cell death are poorly understood. Pathological cells exhibit abnormal deposits, called Lewy bodies, which contain numerous proteins. A major constituent of these protein deposits is alpha-synuclein. It has recently been demonstrated, in the Laboratory of Molecular Biophysics of the CNRS (Scientific Research National Center) in Orleans, that α-synuclein interacts with Cytogaligin, a protein produced by the proapoptotic GALIG gene. Cytogaligin could thus be a factor regulating α-synuclein activity or aggregation. It is postulated that the level of expression of the GALIG gene is different in Parkinson's disease patients compared with control subjects.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Parkinson Disease

Intervention

Blood sampling

Location

CHR d'ORLEANS
Orleans
France
45067

Status

Completed

Source

Centre Hospitalier Régional d'Orléans

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-10-05T00:23:21-0400

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Systemic Synuclein Sampling Study (S4)

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PubMed Articles [22319 Associated PubMed Articles listed on BioPortfolio]

Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4).

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Diagnostic validity of biomarkers in Parkinson's Disease: systematic review and meta-analysis.

To identify biomarkers for Parkinson's disease, cerebrospinal fluid, blood, saliva, and urine.

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Medical and Biotech [MESH] Definitions

Sampling of blood levels of the adrenocorticotropic hormone (ACTH) by withdrawal of blood from the inferior petrosal sinus. The inferior petrosal sinus arises from the cavernous sinus and runs to the internal jugular vein. Sampling of blood at this level is a valuable tool in the differential diagnosis of Cushing disease, Cushing syndrome, and other adrenocortical diseases.

Proteins associated with sporadic or familial cases of PARKINSON DISEASE.

A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots.

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

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