The TREFOIL Concept 5 Year Clinical Investigation

2016-10-21 04:08:21 | BioPortfolio


Prospective, single cohort, multi-center study evaluating the TREFOIL concept for the treatment of edentulous or patients with failing mandibular dentition over 5 years. 90 patients (15 per centre) will be included. The subject population is at least 18 years old, in need of an implant restored full prosthesis providing sufficient bone in the interforaminal where a fixed restoration on three implants is regarded as an appropriate treatment solution. The components are TREFOIL treatment concept (implants and framework).

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


To Evaluate the Cumulative Survival Rates (CSR) of Implants in the Mandible for a Period of 5 Years.


TREFOIL concept


Dr. Higuchi &Skinner
United States




Nobel Biocare

Results (where available)

View Results


Published on BioPortfolio: 2016-10-21T04:08:21-0400

Clinical Trials [1306 Associated Clinical Trials listed on BioPortfolio]

Immediate Function of NobelSpeedy Shorty and Brånemark System® Mk III Shorty Implants in Daily Use

Surgical and restorative procedures in the posterior region of both the mandible and the maxilla present a complex task. The posterior regions usually exhibit less favorable bone quality a...

An Evaluation of Integration Success and Maintenance of Short Implants in Maxillas Needing Sinus Augmentation

This prospective randomized study will evaluate the integration success while supporting a prosthesis for short implants placed into maxillary sites having minimal bone height that would o...

Study on Immediate Loading of Immediately Placed Single Implants.

The purpose of this study is to evaluate survival and success rates of dental implants placed with immediate loading protocol in extraction sockets. All patients were monitored for 1 year ...

Comparison of Extra-short (4 mm) Implants Used as Distal Support of a Maxillary Full-arch Fixed Dental Prosthesis vs. 10 mm Implants Installed After Sinus Floor Elevation.

Recently, 4 mm long implants with a standard diameter have been used for the restoration of the posterior edentulous mandible with favorable results. However, randomized clinical trials re...

Study on OsseoSpeed™ TX Short Implants in a Chinese Population

The purpose of this study is to investigate the clinical efficacy of Osseospeed™ TX 6 mm implants in a Chinese population by evaluation of marginal bone level alteration, implant stabili...

PubMed Articles [19469 Associated PubMed Articles listed on BioPortfolio]

Early loading of splinted implants in posterior mandible: Three-year results of a prospective multicenter study.

To evaluate the clinical outcomes of an early loading protocol of splinted implants with a fluoride-modified nanostructure surface and a tapered-apex design for the therapy of posterior partial edentu...

Treatment Planning the Edentulous Mandible. Review of Biomechanical and Clinical Considerations: An Update.

This review article evaluated biomechanical studies, finite element analyses, and clinical papers on the prosthetic and surgical principles for the survival of implants when reconstructing the edentul...

Long-term retrospective observational cohort study on the survival rate of stepped screw titanium implants followed up to 20 years.

The aim of this long-term retrospective study was twofold: (1) to evaluate the survival and success rates of stepped screw titanium implants with a sandblasted and acid-etched surface, and (2) to asse...

Immediate Loading of Two Unsplinted Implants in Edentulous Patients with Mandibular Overdentures: A 10-year Retrospective Review of Patients from a Previously Conducted 1-year Cohort Study.

This systematic review evaluated the mean survival rate and marginal bone loss (MBL) of dental implants with ≤ 6 mm in length, across a time frame of 5 years. The overall prosthetic and biologic com...

Fixed and Removable Full-Arch Restorations Supported by Short (≤ 8-mm) Dental Implants In the Mandible: A Systematic Review and Meta-Analysis.

To evaluate, through a systematic review of the literature, the published data regarding marginal bone loss, implant failure proportion, biologic and prosthetic complications, and risk factors associa...

Medical and Biotech [MESH] Definitions

The probability distribution associated with two mutually exclusive outcomes; used to model cumulative incidence rates and prevalence rates. The Bernoulli distribution is a special case of binomial distribution.

A 60 amino acid (6.5 kDa) trefoil factor that contains a single trefoil domain. It is expressed primarily by surface EPITHELIAL CELLS of the GASTRIC MUCOSA, where it associates with MUCIN 5AC.

A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.

A 59 amino acid (6.6 kDa) trefoil factor that contains a single trefoil domain. It is expressed in all tissues with MUCOUS MEMBRANES, including GOBLET CELLS of the SMALL INTESTINE and LARGE INTESTINE. It associates with MUCIN-2 in the small intestine and may regulate epithelial CELL MIGRATION and WOUND HEALING.

A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.

More From BioPortfolio on "The TREFOIL Concept 5 Year Clinical Investigation"

Quick Search

Relevant Topics

Arthroplasty is a surgical procedure to restore the integrity and function of a joint. A joint can be restored by resurfacing the bones. An artificial joint (called a prosthesis) may also be used. Various types of arthritis may affect the joints. Osteo...

Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...

Searches Linking to this Trial