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The TREFOIL Concept 5 Year Clinical Investigation

2016-10-21 04:08:21 | BioPortfolio

Summary

Prospective, single cohort, multi-center study evaluating the TREFOIL concept for the treatment of edentulous or patients with failing mandibular dentition over 5 years. 90 patients (15 per centre) will be included. The subject population is at least 18 years old, in need of an implant restored full prosthesis providing sufficient bone in the interforaminal where a fixed restoration on three implants is regarded as an appropriate treatment solution. The components are TREFOIL treatment concept (implants and framework).

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

To Evaluate the Cumulative Survival Rates (CSR) of Implants in the Mandible for a Period of 5 Years.

Intervention

TREFOIL concept

Location

Dr. Higuchi &Skinner
Spokane
Washington
United States
99216-1077

Status

Recruiting

Source

Nobel Biocare

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-10-21T04:08:21-0400

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The probability distribution associated with two mutually exclusive outcomes; used to model cumulative incidence rates and prevalence rates. The Bernoulli distribution is a special case of binomial distribution.

A 60 amino acid (6.5 kDa) trefoil factor that contains a single trefoil domain. It is expressed primarily by surface EPITHELIAL CELLS of the GASTRIC MUCOSA, where it associates with MUCIN 5AC.

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A 59 amino acid (6.6 kDa) trefoil factor that contains a single trefoil domain. It is expressed in all tissues with MUCOUS MEMBRANES, including GOBLET CELLS of the SMALL INTESTINE and LARGE INTESTINE. It associates with MUCIN-2 in the small intestine and may regulate epithelial CELL MIGRATION and WOUND HEALING.

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