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The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
Previous studies have evidenced that ICU acquired peripheral muscle weakness may lead to delayed mechanical ventilation weaning (i.e difficult or prolonged weaning according to guidelines). Nevertheless, no study has ever tested the association between handgrip strength and extubation outcome. We have generated the hypothesis that ICU acquired weakness, as tested by handgrip strength might be associated with extubation outcome. We have planned to include 240 patients. Handgrip strength will be monitored, along with a full muscular assessment through MRC score by the attending physiotherapist. Physicians in charge of the patients will be blinded to these values and the weaning protocol will continue according to guidelines.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Handheld dynamometry (handgrip strength)
Not yet recruiting
Assistance Publique - Hôpitaux de Paris
Published on BioPortfolio: 2016-10-28T05:53:22-0400
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Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).
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The amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER.
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