Dairy Intake and Cerebral Antioxidant Defense in Aging: a Dietary Intervention Study

2016-11-08 09:23:21 | BioPortfolio


The purpose of this study is to learn if increased dairy food consumption helps brain health in older adults by protecting nerve cells from damage.


Eating more dairy foods may improve brain health as people age by increasing the brain's natural defenses to protect nerve cells against chemical stress. Researchers think there may be a relationship between the brain's natural defense system and the amount of dairy food intake. Strengthening these defenses could provide beneficial protection to the brain against neurodegenerative age-related diseases and cognitive decline.

Glutathione (GSH) is a metabolite in the human brain protective system. It plays a key role in protecting cells against oxidative stress, which is one of the major processes contributing to aging and neurodegeneration. Preliminary findings suggest that there may be a correlation between dairy food intake and GSH levels in the aging brain. Magnetic Resonance Spectroscopy (MRS) measures chemicals in the brain. It is a noninvasive measure of the effects of dairy food intake on the major protective metabolite levels in the living human brain in aging.

This study involves using an MRI with special MRS scans to see if adequate dairy food intake may aid in enhancing cerebral protective capacity to fight against age-related disease and cognitive decline in the brain.

Participants will be asked to make a total of six visits to the research site. Participation will last about 3 months.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention


Brain Aging


1% Milk, Dairy


University of Kansas Medical Center
Kansas City
United States


Not yet recruiting


University of Kansas Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2016-11-08T09:23:21-0500

Clinical Trials [1151 Associated Clinical Trials listed on BioPortfolio]

The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults

This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood...

The Effect of Dairy and Non-dairy Breakfasts on Satiety and Post-meal Glycemia in Healthy Older Adults

This study investigates the effects of dairy breakfasts (2% cow's milk, 2% Greek yogurt, cheese) and a non-dairy breakfast (soy beverage) on satiety and post-meal blood glucose. Each parti...


Breast feeding is the most nutritious form of nourishment in infants and is recommended for at least the first four months of life. Breast fed infants may develop milk protein intolerance....

Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat

Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and ...

Postprandial Plasma Amino Acid Concentrations After Dairy Consumption

This study was designed to obtain information about the change in postprandial amino acids in blood over time, after consumption of different dairy products, in an elderly population and h...

PubMed Articles [9016 Associated PubMed Articles listed on BioPortfolio]

Control of Listeria monocytogenes in whole milk using antimicrobials applied individually and in combination.

Dairy product recalls and dairy-related illnesses are often the result of contamination with Listeria monocytogenes, which can occur throughout the dairy production and supply chains. The use of antim...

"Got rats?" Global environmental costs of thirst for milk include acute biodiversity impacts linked to dairy feed production.

Bai et al. (2018) determined that China's increasing milk demand is expected to raise global greenhouse gas (GHG) emissions by 35%, expand dairy land by 32% and lift nitrogen pollution by 48%. Produc...

Investigation on bisphenol A levels in human milk and dairy supply chain: A review.

Bisphenol A (BPA), widely used as additive in food packaging, is an environmental and food contaminant that shows a weak estrogenic activity in general population and toxicity in the infant population...

Evaluation of effects of Mycoplasma mastitis on milk composition in dairy cattle from South Australia.

Mycoplasma mastitis is increasingly posing significant impact on dairy industry. Although the effects of major conventional mastitis pathogens on milk components has been widely addressed in the liter...

Effect of Broussonetia papyrifera L. (paper mulberry) silage on dry matter intake, milk composition, antioxidant capacity and milk fatty acid profile in dairy cows.

This study was carried out to investigate the possible application of B. papyrifera silage as a functional feeding stuff in the dairy cattle. 72 Holstein cows were divided into four groups randomly an...

Medical and Biotech [MESH] Definitions

Raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo.

A rod-shaped bacterium isolated from milk and cheese, dairy products and dairy environments, sour dough, cow dung, silage, and human mouth, human intestinal contents and stools, and the human vagina.

Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.

A non-pathogenic species of LACTOCOCCUS found in DAIRY PRODUCTS and responsible for the souring of MILK and the production of LACTIC ACID.

The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

More From BioPortfolio on "Dairy Intake and Cerebral Antioxidant Defense in Aging: a Dietary Intervention Study"

Quick Search


Relevant Topics

Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Mental Health
Adhd Anorexia Depression Dyslexia Mental Health Psychiatry Schizophrenia Stress Mental health, although not being as obvious as physical health, is very important, causing great unhappiness to those affected, causing add...

Searches Linking to this Trial