Efficacity of Idelalisib and Obinutuzumab in Patient With Relapsed Refractory Waldenstrom's Macroglobulinemia

2016-11-15 11:38:21 | BioPortfolio


Prospective national multicenter open label phase II Remodel WM3 trial


An Open Label non-randomized Phase II Study exploring chemo-free treatment association with Idelalisib and Obinutuzumab in Patient with relapsed refractory Waldenstrom's Macroglobulinemia

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Waldenstrom Macroglobulinemia


Obinutuzumab, Idelalisib


Not yet recruiting


French Innovative Leukemia Organisation

Results (where available)

View Results


Published on BioPortfolio: 2016-11-15T11:38:21-0500

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PubMed Articles [23 Associated PubMed Articles listed on BioPortfolio]

Bilateral vision loss in Waldenstrom's macroglobulinemia.

Waldenström macroglobulinemia. Experience in 31 patients.

Waldenström macroglobulinemia (WM) is an uncommon indolent B-cell lymphoma, due to the proliferation of lymphoplasmacytic cells, and secretion of a monoclonal IgM protein.

PKPD assessment of the anti-CD20 antibody obinutuzumab in cynomolgus monkey is feasible despite marked anti-drug antibody response in this species.

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Imaging of Waldenström Macroglobulinemia: A Comprehensive Review for the Radiologist in the Era of Personalized Medicine.

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Fatal disseminated enterovirus infection in a patient with follicular lymphoma undergoing obinutuzumab maintenance therapy.

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Medical and Biotech [MESH] Definitions

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.

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