Trimodal (18)F-choline-PET/mpMRI/TRUS Targeted Prostate Biopsies

2016-11-25 14:25:35 | BioPortfolio


Prostate cancer is the first cancer in humans (25%). The most widely used tracer in oncology, the 18-Fluoro DeoxyGlucose does not allow the study of prostatic neoplasia. On the other hand, Choline, which is an amino alcohol, is involved in the synthesis of cell membranes and has an affinity for prostate cells. Its concentration is directly proportional to cell proliferation. The analogue of choline has the advantage of having a rapid and stable accumulation over time in cancer cells, with a rapid urinary excretion (4 minutes after injection).

The goal of this study is to assess the feasibility and the accuracy for targeting image guided prostate biopsy to detect prostate cancer after Imaging fusion of choline-PET/CT compared to 1.5T multiparametric magnetic resonance imaging (mpMRI) with 3D-transrectal ultrasound (TRUS) .

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic


Prostatic Neoplasm


PET Scan ou TEP-TDM, mpMRI




Lille Catholic University

Results (where available)

View Results


Published on BioPortfolio: 2016-11-25T14:25:35-0500

Clinical Trials [735 Associated Clinical Trials listed on BioPortfolio]

Prostatic Artery Embolization for Obstructive Uropathy Due to Locally Advanced Prostate Cancer

The aim of this study is to investigate the safety and efficacy of prostatic artery embolization of patients with recurrent symptoms secondary to locally advanced prostatic cancer includin...

Predicting Prostate Biopsy Results With Biomarkers and mpMRI.

Current standard prostate biopsy techniques, used to definitively diagnose prostate cancer (PC), utilises an ultrasound guided biopsy approach, that offers unsatisfactory specificity and s...

Accuracy of mpMRI and MRI-targeted, Ultrasound-navigated Prostate Fusion Biopsy in Detection of Prostate Cancer

We investigated whether a high PI-RADS v2 score correlates with the presence of prostate cancer. In addition, we investigated whether the lesion size as determined by mpMRI correlates with...

MRI Guided SBRT for Localized Prostate Cancer

This study utilizes advanced imaging techniques (mpMRI prostate scan) to select and stratify patients for two different radiotherapy regimens based on the presence/absence of identifiable ...

ConfirmMDx Assay in Multiparametric MRI (mpMRI) PIRADS Scored Lesions After a Negative MR/US Fusion Biopsy

The purpose of this study is to see if the ConfirmMDx assay is useful in finding prostate cancer in patients who are at increased risk for prostate cancer based on elevated PSA and prostat...

PubMed Articles [1205 Associated PubMed Articles listed on BioPortfolio]

Diagnostic accuracy of Ga-prostate-specific membrane antigen (PSMA) positron-emission tomography (PET) and multiparametric (mp)MRI to detect intermediate-grade intra-prostatic prostate cancer using whole-mount pathology: impact of the addition of Ga-PSMA PET to mpMRI.

To evaluate the ability of prostate-specific membrane antigen (PSMA)-positron-emission tomography (PET)/computed tomography (CT) to detect intermediate-grade intra-prostatic prostate cancer (PCa), and...

Towards Reducing Overutilization of Prostate mpMRI: Using Clinical Parameters to Predict Negative and Indeterminate mpMRI Scans.

To develop a triage strategy to reduce negative and indeterminate multiparametric MRI (mpMRI) scans in patients at risk for prostate cancer (PCa).

Genetic correlates of prostate cancer visibility (and invisibility) on mpMRI: It's time to take stock.

Multiparametric magnetic resonance imaging (mpMRI) has enhanced risk stratification for men at risk of prostate cancer, through accurate pre-biopsy detection of high-risk disease [1]. However, it has ...

Prostatic artery embolization in non-index benign prostatic hyperplasia patients: Single center outcomes for urinary retention and gross prostatic hematuria.

To present outcomes for prostatic artery embolization (PAE) to treat urinary retention and gross prostatic hematuria in non-index benign prostatic hyperplasia (BPH) patients.

The role of prostaglandin and EP4 receptors in development of bladder overactivity in a rat model of chemically induced prostatic inflammation.

There is increasing evidence indicating a positive correlation between prostatic inflammation and lower urinary tract symptoms (LUTS) in male with benign prostatic hyperplasia (BPH). Therefore, in the...

Medical and Biotech [MESH] Definitions

The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.

Tissue ablation of the PROSTATE performed by ultrasound from a transducer placed in the RECTUM. The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA).

A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.

More From BioPortfolio on "Trimodal (18)F-choline-PET/mpMRI/TRUS Targeted Prostate Biopsies"

Quick Search

Relevant Topics

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Prostate Cancer
Prostate cancer (cancer de prostata) Prostate cancer (cancer de prostata) is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostat...

Searches Linking to this Trial