Protective Effects of Normobaric Hyperoxia on Blood Brain Barrier in Patients With Acute Ischemic Stroke

2016-11-28 14:53:22 | BioPortfolio


The purpose of this study is to find out a serum marker for the evaluation of blood brain barrier damage based on animal experiments and investigate the effect of NBO(Normobaric hyperoxia)on blood brain barrier in the acute ischemic stroke patients who received r-tPA thrombolytic therapy.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Stroke, Acute


Normobaric oxygen therapy


Not yet recruiting


Capital Medical University

Results (where available)

View Results


Published on BioPortfolio: 2016-11-28T14:53:22-0500

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Medical and Biotech [MESH] Definitions

The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.

Restoration of functions to the maximum degree possible in a person or persons suffering from a stroke.

Sudden death from overwork, most often as a result of acute CARDIOVASCULAR STROKE.

Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.

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