Using 16S rRNA Gene Sequencing Analysis Intestinal Microbiota in Constipation Patients

2016-12-07 17:23:21 | BioPortfolio


Constipation is a frequent, chronic gastroenterological problem that has many varied symptoms and thus has several clinical definitions. According to the Rome III criteria for chronic constipation, almost 16% of all adults are affected by chronic constipation worldwide, and it is more prevalent and symptomatic in women and elderly people. Slow transit constipation (STC) is the major category and is characterized by a decreased rate of colonic transit.

Recently, many researchers have focused on the relationship between intestinal microbiota and constipation and have demonstrated that intestinal microbiota contribute to the pathophysiology of functional gastrointestinal disorders.

Thus, there is a need for an improved understanding of gut microbiota composition in constipation patients and for the potential role played by the gut microbiota in the etiology of STC.To achieve this goal the investigators characterized and compared the intestinal microbiota among carefully selected patients with constipation that were clinically categorized based on Rome III criteria, and healthy controls using high throughput pyrosequencing of the 16S rRNA gene and a conservative approach to detect quantitative changes in the relative abundances of taxa.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Slow Transit Constipation


Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University




Jinling Hospital, China

Results (where available)

View Results


Published on BioPortfolio: 2016-12-07T17:23:21-0500

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