Topics

Using 16S rRNA Gene Sequencing Analysis Intestinal Microbiota in Constipation Patients

2016-12-07 17:23:21 | BioPortfolio

Summary

Constipation is a frequent, chronic gastroenterological problem that has many varied symptoms and thus has several clinical definitions. According to the Rome III criteria for chronic constipation, almost 16% of all adults are affected by chronic constipation worldwide, and it is more prevalent and symptomatic in women and elderly people. Slow transit constipation (STC) is the major category and is characterized by a decreased rate of colonic transit.

Recently, many researchers have focused on the relationship between intestinal microbiota and constipation and have demonstrated that intestinal microbiota contribute to the pathophysiology of functional gastrointestinal disorders.

Thus, there is a need for an improved understanding of gut microbiota composition in constipation patients and for the potential role played by the gut microbiota in the etiology of STC.To achieve this goal the investigators characterized and compared the intestinal microbiota among carefully selected patients with constipation that were clinically categorized based on Rome III criteria, and healthy controls using high throughput pyrosequencing of the 16S rRNA gene and a conservative approach to detect quantitative changes in the relative abundances of taxa.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Slow Transit Constipation

Location

Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University
Nanjing
Jiangsu
China
210000

Status

Recruiting

Source

Jinling Hospital, China

Results (where available)

View Results

Links

Published on BioPortfolio: 2016-12-07T17:23:21-0500

Clinical Trials [521 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety of Fecal Microbiota Transplantation for Slow Transit Constipation

The purpose of this study is to evaluate the effect of fecal microbiota transplantation in adults with slow transit constipation.

Evaluating the Synergism of Soluble Dietary Fiber With Fecal Microbiota Transplantation in Slow Transit Constipation

The purpose of this study is to evaluate the synergism of Soluble Dietary Fiber with Fecal Microbiota Transplantation in Adult Patients with Slow Transit Constipation.

Study of Effect of Tegaserod on Small and Large Bowel Transit by Scintigraphic Method

Functional constipation is a common problem in Hong Kong. In a recent telephone survey, the prevalence of constipation as defined by Rome II criteria was 14%. Apart from organic, metabolic...

Effect of Synbiotic on Symptoms of Patients With STC

To evaluate the efficacy of synbiotic (BIFICOPEC) containing Enterococci, Bifidobacteria, Lactobacilli triple viable bacteria and pectin in patients with slow transit constipation.

Freeze-dried vs Fresh Fecal Microbiota Transplantation in Patients With Slow Transit Constipation

The purpose of this study is to compare the effect of freeze-dried, capsulized FMT and fresh FMT in adults with slow transit constipation.

PubMed Articles [1441 Associated PubMed Articles listed on BioPortfolio]

Normal colonic transit time predicts the outcome of colonic manometry in patients with chronic constipation-an exploratory study.

Colonic manometry (CM) can be of additive value in the diagnostic workup of colonic motility in chronic constipated patients. However, it is claimed that colonic motor disturbances occur in normal-tra...

Heterogeneous outcome reporting in adult slow-transit constipation studies: systematic review towards a core outcome set.

Standardizing evaluative outcomes and their assessment facilitates comparisons between clinical studies and provides a basis for comparing direct effects of different treatment options. The aim of thi...

Mechanisms, Evaluation, and Management of Chronic Constipation.

With a worldwide prevalence of 15%, chronic constipation is one of the most frequent gastrointestinal diagnoses made in ambulatory medicine clinics and is a common source cause for referrals to gastro...

Colonic transit, high-resolution anorectal manometry and MRI defecography study of constipation in Parkinson's disease.

Despite clinical relevance and potential role on the disease pathogenesis, underlying mechanisms of constipation in Parkinson's disease (PD) remain poorly understood. A systematic assessment using com...

'Rapid transit' constipation in children: a possible genesis for irritable bowel syndrome.

Children with chronic idiopathic constipation (CIC) often end up at the surgeon when medical treatments have failed. This opinion piece discusses a recently described pattern of CIC called 'Rapid tran...

Medical and Biotech [MESH] Definitions

Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.

Choleretic used to allay dry mouth and constipation due to tranquilizers.

A diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.

More From BioPortfolio on "Using 16S rRNA Gene Sequencing Analysis Intestinal Microbiota in Constipation Patients"

Quick Search

Relevant Topics

Gastroenterology
Astroesophageal Reflux Disease (GERD) Barrett's Esophagus Celiac Disease Cholesterol Crohn's Disease Gastroenterology Hepatitis Hepatology Irritable Bowel Syndrome (IBS) Pancreatitis Peptic Ulcer Disease...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...


Searches Linking to this Trial